一种基于配体诱导受体修饰的感觉适应分子机制。
A molecular mechanism for sensory adaptation based on ligand-induced receptor modification.
作者信息
Knox B E, Devreotes P N, Goldbeter A, Segel L A
出版信息
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2345-9. doi: 10.1073/pnas.83.8.2345.
Abstract
Physiological responses mediated by cell-surface receptors frequently adapt or "desensitize" (i.e., terminate despite persistent occupancy of receptors by ligand). Binding of ligands to the external domains of a wide variety of surface receptors induces covalent modification of their cytoplasmic domains. A mechanism is presented in which the variety of receptor states generated by ligand binding and covalent modification act together to regulate physiological responsiveness. The development of the model is guided by observations of adaptation for chemotaxis in Escherichia coli and adenylate cyclase activation in Dictyostelium. The general features of the marked response and eventual exact adaptation predicted by the model match those observed in the experimental systems.
摘要
由细胞表面受体介导的生理反应常常会发生适应或“脱敏”（即尽管配体持续占据受体，但反应仍会终止）。配体与多种表面受体的外部结构域结合会诱导其胞质结构域发生共价修饰。本文提出了一种机制，其中由配体结合和共价修饰产生的多种受体状态共同作用来调节生理反应性。该模型的建立基于对大肠杆菌趋化性适应和盘基网柄菌腺苷酸环化酶激活的观察。该模型预测的明显反应和最终精确适应的一般特征与在实验系统中观察到的特征相匹配。
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