Aix Marseille University, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, 13009 Marseille, France.
Int J Mol Sci. 2018 Aug 10;19(8):2353. doi: 10.3390/ijms19082353.
After birth, the development of hematopoietic cells occurs in the bone marrow. Hematopoietic differentiation is finely tuned by cell-intrinsic mechanisms and lineage-specific transcription factors. However, it is now clear that the bone marrow microenvironment plays an essential role in the maintenance of hematopoietic stem cells (HSC) and their differentiation into more mature lineages. Mesenchymal and endothelial cells contribute to a protective microenvironment called hematopoietic niches that secrete specific factors and establish a direct contact with developing hematopoietic cells. A number of recent studies have addressed in mouse models the specific molecular events that are involved in the cellular crosstalk between hematopoietic subsets and their niches. This has led to the concept that hematopoietic differentiation and commitment towards a given hematopoietic pathway is a dynamic process controlled at least partially by the bone marrow microenvironment. In this review, we discuss the evolving view of murine hematopoietic⁻stromal cell crosstalk that is involved in HSC maintenance and commitment towards B cell differentiation.
出生后，造血细胞的发育发生在骨髓中。造血分化受到细胞内在机制和谱系特异性转录因子的精细调节。然而，现在很明显，骨髓微环境在维持造血干细胞（HSC）及其分化为更成熟谱系方面起着至关重要的作用。间充质细胞和成血管细胞有助于形成一个被称为造血龛的保护性微环境，该微环境分泌特定的因子，并与正在发育的造血细胞建立直接接触。最近的一些研究在小鼠模型中解决了涉及造血亚群与其龛之间细胞串扰的特定分子事件。这导致了这样一种观点，即造血分化和朝着特定的造血途径分化是一个动态过程，至少部分受到骨髓微环境的控制。在这篇综述中，我们讨论了涉及 HSC 维持和朝着 B 细胞分化方向分化的小鼠造血-基质细胞串扰的不断发展的观点。
