Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
Int J Mol Sci. 2018 Aug 10;19(8):2357. doi: 10.3390/ijms19082357.
Regulation of allo-immune responses is proposed as a topic for investigation in the current field of organ transplantation. As a regulator, regulatory T cells (Tregs) have received attention due to their ability to control allograft rejection. Concurrently, however, the independent action of Tregs is not enough to achieve tolerance status in many situations. Meanwhile, as a multi-functional regulator, myeloid-derived suppressor cells (MDSCs) can suppress effector T cells as well as induce Tregs or regulatory B cells (Bregs) in certain circumstances. Furthermore, the importance of a crosstalk between MDSCs and natural killer T cells to induce tolerance has been reported. Thus, orchestration between MDSCs, myeloid regulators, T/Bregs and other lymphoid/myeloid regulators can shed light on achieving allogeneic tolerance. Here, we review the current knowledge in terms of immunological regulatory function displayed by MDSCs in the context of organ transplantation. Ideal control of MDSCs would lead to a reduction of allograft rejection and subsequent long-term allograft acceptance.
调节同种免疫反应被提议作为当前器官移植领域的研究课题。作为一种调节剂，调节性 T 细胞（Tregs）因其能够控制同种异体移植物排斥而受到关注。然而，在许多情况下，Tregs 的独立作用不足以达到耐受状态。同时，作为一种多功能调节剂，髓源性抑制细胞（MDSCs）在某些情况下可以抑制效应 T 细胞，并诱导 Tregs 或调节性 B 细胞（Bregs）。此外，已经报道了 MDSCs 与自然杀伤 T 细胞之间的串扰在诱导耐受中的重要性。因此，MDSCs、髓系调节物、T/Bregs 和其他淋巴/髓系调节物之间的协调可以阐明实现同种异体耐受的机制。在这里，我们综述了 MDSCs 在器官移植背景下所表现出的免疫调节功能的最新知识。理想地控制 MDSCs 将导致移植物排斥反应的减少和随后的长期移植物接受。
