School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 61005, Korea.
Int J Mol Sci. 2018 May 15;19(5):1468. doi: 10.3390/ijms19051468.
Myeloid-derived suppressor cells (MDSCs) play roles in immune regulation during neoplastic and non-neoplastic inflammatory responses. This immune regulatory function is directed mainly toward T cells. However, MDSCs also regulate other cell populations, including B cells, during inflammatory responses. Indeed, B cells are essential for antibody-mediated immune responses. MDSCs regulate B cell immune responses directly via expression of effector molecules and indirectly by controlling other immune regulatory cells. B cell-mediated immune responses are a major component of the overall immune response; thus, MDSCs play a prominent role in their regulation. Here, we review the current knowledge about MDSC-mediated regulation of B cell responses.
髓系来源的抑制细胞 (MDSCs) 在肿瘤和非肿瘤炎症反应中发挥免疫调节作用。这种免疫调节功能主要针对 T 细胞。然而，MDSCs 在炎症反应中也调节其他细胞群体，包括 B 细胞。事实上，B 细胞对于抗体介导的免疫反应至关重要。MDSCs 通过表达效应分子直接调节 B 细胞免疫反应，间接通过控制其他免疫调节细胞来调节 B 细胞免疫反应。B 细胞介导的免疫反应是整体免疫反应的主要组成部分；因此，MDSCs 在其调节中起着重要作用。在这里，我们回顾了关于 MDSC 介导的 B 细胞反应调节的现有知识。
