临床前阿尔茨海默病中的淡漠：淡漠评估量表的心理测量学验证。
Apathy in Preclinical Alzheimer's Disease: Psychometric Validation of the Apathy Evaluation Scale.
机构信息
1 Department of Rehabilitation Sciences, University of Texas at El Paso, El Paso, TX, USA.
2 Geriatric Research, Education and Clinical Center, W. S. Middleton Memorial Veterans Hospital, Madison, WI, USA.
出版信息
Am J Alzheimers Dis Other Demen. 2019 Feb;34(1):16-22. doi: 10.1177/1533317518794020. Epub 2018 Aug 14.
OBJECTIVES
The purpose of the present study was to validate the Apathy Evaluation Scale, self-rated version (AES-S), and assess the severity of apathy in a cognitively healthy middle-aged cohort at risk for Alzheimer's disease (AD).
METHOD
Three hundred and sixteen middle-aged adults were selected to represent a subset of the Wisconsin Alzheimer's Disease Research Center Clinical Core: the Investigating Memory in People At-risk, Causes and Treatments cohort.
RESULTS
An exploratory factor analysis (EFA) with varimax rotation identified 3 subscales: apathy, disinterest, and social withdrawal factors. Confirmatory factor analysis confirmed the EFA findings. Results indicated acceptable convergent and discriminant validity. The AES-S is a reliable instrument to quantify apathy in cognitively healthy middle-aged individuals at risk for AD.
DISCUSSION
This study demonstrates the AES-S is a psychometrically sound measurement tool for assessing levels of apathy in a cognitively healthy middle-aged cohort at risk for AD.
目的
本研究旨在验证自评版淡漠评估量表（AES-S），并评估认知健康的中年阿尔茨海默病（AD）高危人群的淡漠严重程度。
方法
从威斯康星州阿尔茨海默病研究中心临床核心的“有记忆障碍风险人群的病因和治疗研究”队列中选取了 316 名中年成年人作为研究对象。
结果
采用方差极大旋转的探索性因子分析（EFA）确定了 3 个亚量表：淡漠、兴趣缺失和社会退缩因子。验证性因子分析证实了 EFA 的结果。研究结果表明该量表具有可接受的聚合效度和区分效度。AES-S 是一种可靠的工具，可用于量化认知健康的中年 AD 高危人群的淡漠程度。
讨论
本研究表明，AES-S 是一种用于评估认知健康的中年 AD 高危人群淡漠程度的具有良好心理测量学特性的测量工具。
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