O'Donoghue Emma, Clark Abigail, Richardson Matthew, Hodsoll John, Nandha Sunil, Morris Eric, Kane Fergus, O'Keeffe Deirdre, Butler Lucy, Jolley Suzanne
South London and Maudsley NHS Foundation Trust, London, SE5 8AZ, UK.
South London and Maudsley NHS Foundation Trust, 308-312 Brixton Road, London, SW9 6AA, UK.
Trials. 2018 Aug 13;19(1):436. doi: 10.1186/s13063-018-2789-y.
Bipolar disorder is a chronic and disabling psychiatric condition, characterised by recurrent episodes of mania, hypomania and depression. It places a heavy burden on sufferers and families, with high societal and healthcare costs. Many service users with a diagnosis of bipolar disorder also experience prominent psychotic symptoms, with differential diagnoses of schizoaffective disorder, and relapses characterised by repeated manic psychotic episodes and grandiosity. Such presentations require specific adaptations to standard bipolar disorder interventions in order to address their psychosis, alongside mood regulation, with a particular emphasis on impulsivity, irritability, disinhibition and elation. The Balancing ACT study aims to evaluate an innovative group intervention combining Acceptance and Commitment Therapy and psychoeducation approaches (ACT/PE) with individuals experiencing bipolar disorder and/or symptoms within community psychosis services.
The Balancing ACT study is a randomised controlled trial comparing Balancing ACT groups (ACT/PE) plus routine care to routine care alone. Balancing ACT (ACT/PE) comprises ten group sessions, each lasting 2 hours, delivered weekly. The primary outcome is psychological wellbeing; secondary outcomes are mental health relapses (measured by service use averages for the 12 months pre baseline and 3 months post baseline). We will also measure mood, distress, recovery and psychological change processes. Participants will be randomised in a 1:1 ratio, after baseline assessment. Outcomes will be assessed by trained assessors blind to treatment condition at 0, 10 and 14 weeks. Recruitment began in April 2017 and is on-going until the end of October 2017.
The Balancing ACT study will contribute to the currently limited evidence base for psychological interventions for people experiencing bipolar disorder and/or symptoms in the context of community psychosis services.
ISRCTN73327972 . Registered on 27 March 2017. Balancing ACT: evaluating the effectiveness of psychoeducation and Acceptance and Commitment Therapy (ACT) groups for people with bipolar disorder.
双相情感障碍是一种慢性致残性精神疾病，其特征为躁狂、轻躁狂和抑郁反复发作。它给患者及其家庭带来沉重负担，造成高昂的社会和医疗成本。许多被诊断为双相情感障碍的服务使用者还会出现明显的精神病性症状，需要与精神分裂症伴情感障碍进行鉴别诊断，且复发表现为反复的躁狂精神病性发作和夸大观念。此类表现需要对标准双相情感障碍干预措施进行特殊调整，以便在调节情绪的同时应对其精神病性症状，尤其要关注冲动性、易怒、行为脱抑制和欣快症状。“平衡ACT研究”旨在评估一种创新的团体干预措施，该措施将接纳与承诺疗法和心理教育方法（ACT/PE）相结合，应用于社区精神病服务中患有双相情感障碍和/或有相关症状的个体。
“平衡ACT研究”是一项随机对照试验，将平衡ACT组（ACT/PE）加常规护理与单纯常规护理进行比较。平衡ACT（ACT/PE）包括十次团体治疗，每次持续2小时，每周进行一次。主要结局指标为心理健康状况；次要结局指标为精神健康复发情况（通过基线前12个月和基线后3个月的服务使用平均值来衡量）。我们还将测量情绪、痛苦、康复情况以及心理变化过程。在基线评估后，参与者将按1:1的比例随机分组。结局将由对治疗条件不知情的经过培训的评估人员在第0、10和14周进行评估。招募工作于2017年4月开始，持续至2017年10月底。
“平衡ACT研究”将为目前社区精神病服务背景下针对双相情感障碍和/或有相关症状患者的心理干预有限的证据基础做出贡献。
ISRCTN73327972。于2017年3月27日注册。平衡ACT：评估心理教育和接纳与承诺疗法（ACT）团体对双相情感障碍患者的有效性。
