University of Lille, EA4489, Equipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, F-59000 Lille, France; Department of Medicine (H7), Karolinska Institutet, 141 86 Stockholm, Sweden.
Department of Medicine (H7), Karolinska Institutet, 141 86 Stockholm, Sweden.
Trends Endocrinol Metab. 2018 Oct;29(10):675-685. doi: 10.1016/j.tem.2018.07.004. Epub 2018 Aug 10.
An adverse nutritional environment during the perinatal period increases the risk of adult-onset metabolic diseases, such as obesity, which may persist across generations. Adipose tissue (AT) from offspring of malnourished dams has been shown to display altered adipogenesis, lipogenesis, and adipokine expression, impaired thermogenesis, and low-grade inflammation. Although the exact mechanisms underlying these alterations remain unclear, epigenetic processes are believed to have an important role. In this review, we focus on epigenetic mechanisms in AT that may account for transgenerational dysregulation of adipocyte formation and adipose function. Understanding the complex interactions between maternal diet and epigenetic regulation of the AT in offspring may be valuable in improving preventive strategies against the obesity pandemic.
围产期不良营养环境会增加成年后代谢性疾病（如肥胖症）的风险，且这种风险可能会在代际间传递。研究表明，营养不良的母鼠后代的脂肪组织（AT）表现出脂肪生成、脂肪生成和脂肪因子表达改变、产热受损和低度炎症。尽管这些改变的确切机制尚不清楚，但表观遗传过程被认为起着重要作用。在这篇综述中，我们重点关注 AT 中的表观遗传机制，这些机制可能导致脂肪细胞形成和脂肪功能的跨代失调。了解母体饮食与后代 AT 的表观遗传调控之间的复杂相互作用，对于改善预防肥胖症大流行的策略可能具有重要价值。
