Clarke Nathan A, Akeroyd Michael A, Henshaw Helen, Hoare Derek J
Medical Research Council Institute of Hearing Research, School of Medicine, The University of Nottingham, University Park, Nottingham, UK.
National Institute of Health Research Nottingham Biomedical Research Centre, Nottingham, UK.
BMJ Open. 2018 Aug 13;8(8):e023700. doi: 10.1136/bmjopen-2018-023700.
Subjective tinnitus is very common and has a number of comorbid associations including depression, sleep disturbance and concentration difficulties. Concentration difficulties may be observable in people with tinnitus through poorer behavioural performance in tasks thought to measure specific cognitive domains such as attention and memory (ie, cognitive performance). Several reviews have discussed the association between tinnitus and cognition; however, none to date have investigated the association between tinnitus and cognitive performance through meta-analysis with reference to an established theoretical taxonomy. Furthermore, there has been little overlap between sets of studies that have been included in previous reviews, potentially contributing to the typically mixed findings that are reported.
This systematic review aims to comprehensively review the literature using an established theoretical taxonomy and quantitatively synthesise relevant data to determine associations between subjective tinnitus and cognitive performance. Methods are reported according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. All study designs will be eligible for inclusion with no date restrictions on searches. Studies eligible for inclusion must contain adult participants (≥18 years) with subjective tinnitus and a behavioural measure of cognitive performance. Meta-analysis will be reported via correlation for the association between tinnitus and cognitive performance.
No ethical issues are foreseen. Findings will be reported in a student thesis, at national and international , ear, nose and throat/audiology conferences and by peer-reviewed publication.
CRD42018085528.
主观性耳鸣非常常见，且有多种共病关联，包括抑郁、睡眠障碍和注意力不集中。耳鸣患者可能在旨在测量特定认知领域（如注意力和记忆力，即认知表现）的任务中表现出较差的行为表现，从而可观察到注意力不集中的情况。已有数篇综述讨论了耳鸣与认知之间的关联；然而，迄今为止，尚无研究通过基于既定理论分类法的荟萃分析来探究耳鸣与认知表现之间的关联。此外，以往综述纳入的研究集之间几乎没有重叠，这可能导致了所报道的结果通常参差不齐。
本系统综述旨在使用既定的理论分类法全面回顾文献，并对相关数据进行定量综合分析，以确定主观性耳鸣与认知表现之间的关联。方法按照系统综述和荟萃分析方案的首选报告项目进行报告。所有研究设计均符合纳入标准，搜索无日期限制。纳入的研究必须包含患有主观性耳鸣的成年参与者（≥18岁）以及认知表现的行为测量指标。将通过耳鸣与认知表现之间关联的相关性报告荟萃分析结果。
预计不存在伦理问题。研究结果将在一篇学生论文中报告，也会在国内和国际的耳鼻喉科/听力学会议上报告，并通过同行评审发表。
PROSPERO注册号：CRD42018085528。
