非中枢神经系统癌症幸存者的认知功能和与工作相关的结局：系统评价和荟萃分析的方案。

Cognitive functioning and work-related outcomes of non-central nervous system cancer survivors: protocol for a systematic review with meta-analysis.

机构信息

Center for Health Technology and Services Research (CINTESIS@RISE), Department of Education and Psychology, University of Aveiro, Aveiro, Portugal

Department of Education and Psychology, University of Aveiro, Aveiro, Portugal.

出版信息

BMJ Open. 2022 Jul 12;12(7):e060300. doi: 10.1136/bmjopen-2021-060300.

DOI:10.1136/bmjopen-2021-060300

PMID:35820744

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277407/

Abstract

INTRODUCTION

In recent years, growing attention has been given to the study of the impact of cancer-related cognitive impairment (CRCI) in working non-central nervous system (CNS) cancer survivors. Available literature has shown that working cancer survivors identify cognitive problems at work as very problematic and worrisome. Some reviews have discussed the association between CRCI and work-related outcomes; however, none to date have investigated this association through comprehensive systematic review with meta-analysis. Hence, this work will comprehensively summarise existing evidence from quantitative studies assessing the relationship between CRCI and work-related outcomes of adult non-CNS cancer survivors at working age.

METHODS AND ANALYSIS

The systematic review procedures and its report will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Electronic searches in the databases Web of Science, Scopus, PubMed, ProQuest, PsycINFO and CINAHL, complemented by a manual search of other relevant articles, will be performed from 2000 onwards to identify relevant publications. Two independent reviewers will assess studies for inclusion and extract data from each article using a standardised form. Studies eligible for inclusion must be quantitative, contain adult non-CNS cancer survivors with CRCI, and a measure of cognitive functioning and work-related outcomes. To assess risk of bias, the Joanna Briggs Institute Critical Appraisal Tool Studies checklists will be independently used by the two researchers. Synthesis of the included articles will be conducted using a narrative method and through meta-analysis. Meta-analysis will be reported via correlation for the association between CRCI and work-related outcomes. The cumulative evidence will be assessed using the Grading of Recommendations Assessment, Development and Evaluation system.

ETHICS AND DISSEMINATION

Ethics approval is not required since individual patient data will not be collected. The findings will be published in a peer-review indexed journal, presented at scientific meetings and included in a chapter of a Doctoral thesis.

PROSPERO REGISTRATION NUMBER

CRD42020165458.

摘要

简介

近年来，人们越来越关注癌症相关认知障碍（CRCI）对非中枢神经系统（CNS）癌症幸存者工作的影响。现有文献表明，在职癌症幸存者认为工作中的认知问题非常严重和令人担忧。一些综述讨论了 CRCI 与与工作相关的结果之间的关联；然而，迄今为止，还没有通过综合系统评价和荟萃分析来研究这种关联。因此，这项工作将全面总结现有的定量研究证据，评估成年非 CNS 癌症幸存者在工作年龄时 CRCI 与与工作相关的结果之间的关系。

方法和分析

系统评价程序及其报告将遵循系统评价和荟萃分析的首选报告项目声明。从 2000 年起，将在 Web of Science、Scopus、PubMed、ProQuest、PsycINFO 和 CINAHL 数据库中进行电子检索，并辅以对其他相关文章的手动搜索，以确定相关出版物。两名独立评审员将评估研究的纳入情况，并使用标准化表格从每篇文章中提取数据。符合纳入标准的研究必须是定量的，包含有 CRCI 的成年非 CNS 癌症幸存者，以及认知功能和与工作相关的结果的测量。为了评估偏倚风险，两位研究人员将独立使用 Joanna Briggs 研究所批判性评估工具研究清单。将通过叙述性方法和荟萃分析对纳入的文章进行综合。通过相关性报告荟萃分析，评估 CRCI 与与工作相关的结果之间的关联。使用推荐评估、制定和评估系统（Grading of Recommendations Assessment, Development and Evaluation system）评估累积证据。