Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Department of Health Information, Shaanxi Provincial Center for Disease Control and Prevention, Xi'an, China.
Sci Rep. 2018 Aug 13;8(1):12014. doi: 10.1038/s41598-018-30514-6.
The aim of this study was to assess the effect of low maternal weight at pre-pregnancy and the average gestational weight gain on undernourished children and their intellectual development. From October 2012 to September 2013, we followed 1744 offspring of women who participated in a trial conducted from 2002 to 2006. Pregnant women recruited in the original trial could receive three prenatal health checks for free, at which maternal weight and height were measured. WISC-IV was used to estimate the intellectual development of children. Weight and height of both pregnant women and children were measured by trained anthropometrists using standard procedures. Having low maternal weight at pre-pregnancy was associated with an increased risk of undernutrition amongst children (underweight: OR = 2.02, 95%CI: 1.14-3.56, thinness: OR = 2.79, 95%CI: 1.50-5.17) and a decrease in verbal comprehension index (-2.70 points, 95%CI: -4.95-0.44) of children. The effect of average gestational weight gain on occurrences of underweight children (OR = 0.08, 95%CI: 0.01-0.55) was also found. We identified the effect of maternal pre-pregnancy underweight on impairment of the separate intellectual domains (verbal comprehension index) and increasing occurrence of undernourished children. Average gestational weight gain was positively associated with a decreased prevalence of underweight children but not with the intellectual development of children in rural China.
本研究旨在评估孕妇孕前低体重和妊娠期平均增重对儿童营养不足和智力发育的影响。2012 年 10 月至 2013 年 9 月，我们对 1744 名参加 2002 年至 2006 年进行的一项试验的女性的子女进行了随访。原始试验中招募的孕妇可以免费接受三次产前健康检查，在此期间测量了母亲的体重和身高。使用 WISC-IV 评估儿童的智力发育。由经过培训的人体测量员使用标准程序测量孕妇和儿童的体重和身高。孕妇孕前低体重与儿童营养不足（体重不足：OR=2.02，95%CI：1.14-3.56；消瘦：OR=2.79，95%CI：1.50-5.17）的风险增加以及儿童言语理解指数（-2.70 分，95%CI：-4.95-0.44）降低有关。还发现妊娠期平均增重对体重不足儿童的发生（OR=0.08，95%CI：0.01-0.55）的影响。我们发现了孕妇孕前体重不足对儿童智力发育（言语理解指数）各单独领域受损以及营养不足儿童发生的影响。妊娠期平均增重与体重不足儿童的患病率降低呈正相关，但与中国农村儿童的智力发育无关。
