Lopez D M, Voigt W
Cancer Res. 1977 Jul;37(7 Pt 1):2057-61.
An experimental animal model for the study of host-prostatic tumor cell interactions has been described. R-3327, a line of prostatic adenocarcinoma of the Copenhagen rat, has been proven to be immunogenic to its syngeneic host as evidenced by two different in vitro cell-mediated immune assays. Specificity of the responses has been ascertained on the basis of absence of response: (a) of nonimmune lymphocytes to the R-3327 tumor antigen(s); (b) of R-3327 immune lymphocytes to several normal tissues including normal prostate; (c) of immune lymphocytes to unrelated squamous cell prostatic carcinoma of the Copenhagen rat. Furthermore, the presence of tumor has an effect in several nonspecific aspects of host response, inducing splenomegaly, heightened responses to nonspecific mitogens in lymphocyte transformation assay, and increased levels of killer cell action. Since there are many histological, biochemical, and functional analogies between this tumor line and human prostate carcinomas, this system appears to be suitable for immunological and possible immunotherapeutic studies of this type of neoplasia.
已描述了一种用于研究宿主与前列腺肿瘤细胞相互作用的实验动物模型。R-3327是哥本哈根大鼠的前列腺腺癌系，通过两种不同的体外细胞介导免疫测定法已证明它对同基因宿主具有免疫原性。已根据以下无反应情况确定了反应的特异性：(a)非免疫淋巴细胞对R-3327肿瘤抗原无反应；(b)R-3327免疫淋巴细胞对包括正常前列腺在内的几种正常组织无反应；(c)免疫淋巴细胞对哥本哈根大鼠无关的鳞状细胞前列腺癌无反应。此外，肿瘤的存在在宿主反应的几个非特异性方面有影响，导致脾肿大、淋巴细胞转化试验中对非特异性有丝分裂原的反应增强以及杀伤细胞活性水平增加。由于该肿瘤系与人类前列腺癌之间存在许多组织学、生化和功能上的相似之处，该系统似乎适用于此类肿瘤的免疫学及可能的免疫治疗研究。
