The Dunning R3327 prostate adenocarcinoma in the Fischer-Copenhagen F1 rat: a useful model for immunological studies.

The Dunning R3327 tumor sublines in the Fischer-Copenhagen F1 rat provide a spectrum of transplantable prostate adenocarcinomas for the study of host-tumor interactions. The tumor can be transplanted with both fresh and cryopreserved cell suspensions. The F1 rat is an appropriate animal for immunological studies based on humoral and cellular immune responses. Preliminary evidence of the host-tumor relationship in the F1 rat indicates that purified membrane preparations induced a specific cytotoxic population of lymphocytes.