密码子优化性差作为一种信号，用于降解发生移码的转录本。
Poor codon optimality as a signal to degrade transcripts with frameshifts.
作者信息
Schikora-Tamarit Miquel Àngel, Carey Lucas B
机构信息
a Systems Bioengineering Program, Department of Experimental and Health Sciences , Universitat Pompeu Fabra , Barcelona , Spain.
出版信息
Transcription. 2018;9(5):327-333. doi: 10.1080/21541264.2018.1511676. Epub 2018 Aug 28.
Abstract
Frameshifting errors are common and mRNA quality control pathways, such as nonsense-mediated decay (NMD), exist to degrade these aberrant transcripts. Recent work has shown the existence of a genetic link between NMD and codon-usage mediated mRNA decay. Here we present computational evidence that these pathways are synergic for removing frameshifts.
摘要
移码错误很常见，并且存在诸如无义介导的衰变（NMD）等mRNA质量控制途径来降解这些异常转录本。最近的研究表明，NMD与密码子使用介导的mRNA衰变之间存在遗传联系。在此，我们提供计算证据表明这些途径在去除移码方面具有协同作用。
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