非编码 RNA 降解途径的分支性质。
The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway.
机构信息
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, USA; Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Trends Genet. 2021 Feb;37(2):143-159. doi: 10.1016/j.tig.2020.08.010. Epub 2020 Sep 29.
Abstract
Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control mechanism in all eukaryotes that regulates the expression of a significant fraction of both the aberrant and normal transcriptomes. In vertebrates, NMD has become an essential process owing to expansion of the diversity of NMD-regulated transcripts, particularly during various developmental processes. Surprisingly, however, some core NMD factors that are essential for NMD in simpler organisms appear to be dispensable for vertebrate NMD. At the same time, numerous NMD enhancers and suppressors have been identified in multicellular organisms including vertebrates. Collectively, the available data suggest that vertebrate NMD is a complex, branched pathway wherein individual branches regulate specific mRNA subsets to fulfill distinct physiological functions.
摘要
无意义介导的 mRNA 降解（NMD）是所有真核生物中一种保守的翻译偶联质量控制机制，可调节异常和正常转录组的很大一部分基因的表达。在脊椎动物中，由于 NMD 调节的转录本多样性的扩展，特别是在各种发育过程中，NMD 已成为一个必需的过程。然而，令人惊讶的是，一些对于简单生物体 NMD 至关重要的核心 NMD 因子似乎对于脊椎动物 NMD 来说是可有可无的。同时，在包括脊椎动物在内的多细胞生物中已经鉴定出许多 NMD 增强子和抑制剂。总的来说，现有数据表明，脊椎动物 NMD 是一个复杂的分支途径，其中各个分支调节特定的 mRNA 亚群以实现不同的生理功能。
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