Department of Histology and Embryology, Clinical Anatomy and Reproductive Medicine Application Institute, University of South China, Hengyang, Hunan 421001, P.R. China.
Department of Pharmacology, Hunan University of Medicine, Huaihua, Hunan 418000, P.R. China.
Int J Oncol. 2018 Nov;53(5):1827-1835. doi: 10.3892/ijo.2018.4520. Epub 2018 Aug 9.
The novel neurite outgrowth inhibitor B (Nogo‑B) receptor (NgBR) is specific for Nogo‑B, which is highly expressed in various human organs and cells, including the lung, liver, kidney, smooth muscle cells, blood vessel endothelial cells and inflammatory cells. Previous studies have indicated that NgBR directly interacts with Nogo‑B and is able to independently influence lipid and cholesterol homeostasis, angiogenesis, N‑glycosylation, the epithelial-mesenchymal transition, the chemotaxis of endothelial cells and cellular proliferation and apoptosis. These multiple functions and actions of this receptor provide an understanding of the important roles of NgBR in various conditions, including fatty liver, atherosclerosis, intracranial microaneurysms, retinitis pigmentosa and severe neurological impairment. Furthermore, NgBR has been demonstrated to exert protean, multifunctional and enigmatic effects in cancer. The present review summarizes the latest knowledge on the suppressing and activating effects of NgBR, emphasizing its function in cancer. Further basic and medical research on this receptor may provide novel insight into its clinical implications on the prognosis of relevant human cancer types.
新型神经突生长抑制因子 B（Nogo-B）受体（NgBR）是 Nogo-B 的特异性受体，Nogo-B 在多种人类器官和细胞中高度表达，包括肺、肝、肾、平滑肌细胞、血管内皮细胞和炎性细胞。先前的研究表明，NgBR 可直接与 Nogo-B 相互作用，并能够独立影响脂质和胆固醇稳态、血管生成、N-糖基化、上皮-间充质转化、内皮细胞趋化性以及细胞增殖和凋亡。该受体的这些多种功能和作用为理解 NgBR 在包括脂肪肝、动脉粥样硬化、颅内微动脉瘤、色素性视网膜炎和严重神经损伤等各种情况下的重要作用提供了依据。此外，NgBR 已被证明在癌症中具有多样、多功能和神秘的作用。本综述总结了 NgBR 的抑制和激活作用的最新知识，强调了其在癌症中的功能。对该受体的进一步基础和医学研究可能为其在相关人类癌症类型的预后中的临床意义提供新的见解。
