Long Shuang-Lian, Li Yu-Kun, Xie Yuan-Jie, Long Zhi-Feng, Shi Jin-Feng, Mo Zhong-Cheng
Department of Histology and Embryology, Clinical Anatomy and Reproductive Medicine Application Institute, University of South China , Hengyang, China .
DNA Cell Biol. 2017 Dec;36(12):1142-1150. doi: 10.1089/dna.2017.3813. Epub 2017 Oct 23.
Members of the reticulon protein family are predominantly distributed within the endoplasmic reticulum. The neurite outgrowth inhibitor (Nogo) has three subtypes, including Nogo-A (200 kDa), Nogo-B (55 kDa), and Nogo-C (25 kDa). Nogo-A and Nogo-C are potent Nogos that are predominantly expressed in the central nervous system. Nogo-B, the splice variant of reticulon-4, is expressed widely in multiple human organ systems, including the liver, lung, kidney, blood vessels, and inflammatory cells. Moreover, the Nogo-B receptor (NgBR) can interact with Nogo-B and can independently affect nervous system regeneration, the chemotaxis of endothelial cells, proliferation, and apoptosis. In recent years, it has been demonstrated that NgBR plays an important role in human pathophysiological processes, including lipid metabolism, angiogenesis, N-glycosylation, cell apoptosis, chemoresistance in human hepatocellular carcinoma, and epithelial-mesenchymal transition. The pathophysiologic effects of NgBR have garnered increased attention, and the detection and enhancement of NgBR expression may be a novel approach to monitor the development and to improve the prognosis of relevant human clinical diseases.
网织蛋白家族成员主要分布在内质网中。神经突生长抑制因子（Nogo）有三种亚型，包括Nogo-A（200 kDa）、Nogo-B（55 kDa）和Nogo-C（25 kDa）。Nogo-A和Nogo-C是主要在中枢神经系统表达的强效Nogos。Nogo-B是网织蛋白-4的剪接变体，广泛表达于多种人体器官系统，包括肝脏、肺、肾脏、血管和炎症细胞。此外，Nogo-B受体（NgBR）可与Nogo-B相互作用，并可独立影响神经系统再生、内皮细胞趋化性、增殖和凋亡。近年来，已证明NgBR在人类病理生理过程中发挥重要作用，包括脂质代谢、血管生成、N-糖基化、细胞凋亡、人类肝细胞癌的化疗耐药性以及上皮-间质转化。NgBR的病理生理作用已受到越来越多的关注，检测和增强NgBR表达可能是监测相关人类临床疾病发展和改善预后的一种新方法。
