Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China.
Oncol Rep. 2018 Oct;40(4):1831-1842. doi: 10.3892/or.2018.6635. Epub 2018 Aug 7.
Lung cancer is the top cause of cancer‑associated mortality in men and women worldwide. Small cell lung cancer (SCLC) is a subtype that constitutes ~15% of all lung cancer cases. Long non‑coding RNAs (lncRNAs), possessing no or limited protein‑coding ability, have gained extensive attention as a potentially promising avenue by which to investigate the biological regulation of human cancer. lncRNAs can modulate gene expression at the transcriptional, post‑transcriptional and epigenetic levels. The current review highlights the developing clinical implications and functional roles of lncRNAs in SCLC, and provides directions for their future utilization in the diagnosis and treatment of SCLC.
肺癌是全球男性和女性癌症相关死亡的首要原因。小细胞肺癌（SCLC）是一种占所有肺癌病例约 15%的亚型。长链非编码 RNA（lncRNA），没有或仅有有限的蛋白质编码能力，作为一种潜在的有前途的途径，引起了广泛的关注，可用于研究人类癌症的生物学调控。lncRNA 可以在转录、转录后和表观遗传水平上调节基因表达。本综述强调了 lncRNA 在 SCLC 中的临床应用和功能作用的发展，并为它们在 SCLC 的诊断和治疗中的未来应用提供了方向。
