Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China.
The Key Laboratory of Carcinogenesis of The Chinese Ministry of Health, School of Basic Medical Sciences, Central South University, Changsha, Hunan 410078, P.R. China.
Int J Oncol. 2019 Sep;55(3):585-596. doi: 10.3892/ijo.2019.4850. Epub 2019 Jul 29.
Lung cancer is the most common malignancy with the highest mortality worldwide. Emerging research has demonstrated that long non‑coding RNAs (lncRNAs), a key genomic product, are commonly dysregulated in lung cancer and have significant functions in lung cancer initiation, progression and therapeutic response. lncRNAs may interact with DNA, RNA or proteins, as tumor suppressor genes or oncogenes, to regulate gene expression and cell signaling pathways. In the present review, first a summary was presented of the causal effects of dysregulated lncRNAs in lung cancer. Next, the function and specific mechanisms of lncRNA‑mediated tumorigenesis, metastasis and drug resistance in lung cancer were discussed. Finally, the potential roles of lncRNAs as biomarkers for lung cancer were explored.
肺癌是全球最常见的恶性肿瘤，也是死亡率最高的肿瘤。新的研究表明，长链非编码 RNA（lncRNA）作为一种关键的基因组产物，在肺癌中通常失调，并在肺癌的发生、进展和治疗反应中具有重要功能。lncRNA 可以与 DNA、RNA 或蛋白质相互作用，作为肿瘤抑制基因或癌基因，调节基因表达和细胞信号通路。在本综述中，首先总结了失调的 lncRNA 在肺癌中的因果作用。接下来，讨论了 lncRNA 介导的肺癌发生、转移和耐药性的功能和特定机制。最后，探讨了 lncRNA 作为肺癌标志物的潜在作用。
