Mathur S P, Patni N, Popli M K, Dev P K
Acta Radiol Oncol. 1986 Jan-Feb;25(1):77-80. doi: 10.3109/02841868609136382.
Pregnant Swiss albino mice were given on day 11.25 post conception a priming intraperitoneal (i.p.) injection of tritiated water at the activity levels 37, 74 or 185 kBq/ml body water, in the absence (control) or presence (experimental) of 2-mercaptopropionylglycine (MPG), 20 mg/kg body weight, given intraperitoneally 30 minutes before the tritium administration. The females were subsequently maintained on tritiated drinking water until term, at the above activity level, in the control series. The animals of the experimental series received in addition a daily i.p. injection of MPG at the same time of the day, until term. A third series received a daily injection of the drug, but no tritium, at the same dose rate. None of the females from the control series had parturition, and a gradual decline in their weight was recorded, exhibiting resorption. Treatment with MPG led to an obvious increase in embryonic survival in all groups, and even in the 185 kBq group two-thirds of the females had parturition.
在受孕后第11.25天，给怀孕的瑞士白化小鼠腹腔内注射不同活度水平（37、74或185 kBq/ml体重水）的氚水进行预激发。在不存在（对照）或存在（实验）2-巯基丙酰甘氨酸（MPG）的情况下进行注射，MPG剂量为20 mg/kg体重，在给予氚前30分钟腹腔内注射。随后，对照组的雌性小鼠持续饮用含氚的水直至足月，氚水活度保持上述水平。实验组的动物除了饮用含氚水外，每天在同一时间腹腔内注射MPG直至足月。第三组每天以相同剂量率注射药物，但不注射氚。对照组的雌性小鼠均未分娩，体重逐渐下降，胚胎出现吸收。MPG处理使所有组的胚胎存活率显著提高，即使在185 kBq组中，也有三分之二的雌性小鼠分娩。
