Dev P K, Pareek B P, Goyal P K, Mehta G, Gupta S M
Acta Anat (Basel). 1983;116(4):339-45. doi: 10.1159/000145758.
Pregnant Swiss albino mice were whole-body exposed to 250, 150 and 50 R gamma-radiation from 60Co in the presence or absence of 2-mercaptopropionylglycine during selective organogenesis and fetal growth periods (days 11.25 and 14.25, 16.25 and 18.25 after conception, respectively). Both the protected and nonprotected pregnant females of 11.25-day gestation showed complete resorption of embryos irradiated with 250 R. With 150 R, in absence of the drug, 11.25-day gestating females showed partial resorption (76.10%). The percentage of parturition improved in the drug-treated females. Non-protected females irradiated with 50 R showed slight resorption, while drug-treated females had normal parturition. Females irradiated during the fetal growth period showed no resorption. Also, no significant alteration in litter size and sex ratio of the newborn animals was noticed when irradiated during this period, both in the control and the experimental groups. Mortality of the young was higher in nonprotected animals as compared to the protected ones.
在选择性器官发生期和胎儿生长发育期（分别为受孕后第11.25天和14.25天、16.25天和18.25天），将怀孕的瑞士白化小鼠全身暴露于来自60Co的250、150和50伦琴的γ射线辐射下，同时存在或不存在2-巯基丙酰甘氨酸。妊娠11.25天的受保护和未受保护的怀孕雌性小鼠，接受250伦琴辐射的胚胎均完全吸收。对于150伦琴辐射，在无药物的情况下，妊娠11.25天的雌性小鼠出现部分吸收（76.10%）。药物处理的雌性小鼠分娩百分比有所提高。接受50伦琴辐射的未受保护雌性小鼠出现轻微吸收，而药物处理的雌性小鼠正常分娩。在胎儿生长发育期接受辐射的雌性小鼠未出现吸收情况。此外，在此期间接受辐射时，对照组和实验组新生动物的窝仔数和性别比例均未出现显著变化。与受保护的动物相比，未受保护的动物幼崽死亡率更高。
