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2-巯基丙酰甘氨酸对子宫内受照射小鼠生长抑制作用的保护作用。

2-Mercaptopropionylglycine protection against growth-inhibiting effects in utero irradiated mice.

作者信息

Dev P K, Pareek B P, Gupta S M, Goyal P K, Mehta G

出版信息

Acta Anat (Basel). 1982;112(3):249-53. doi: 10.1159/000145517.

DOI:10.1159/000145517
PMID:7102249
Abstract

Pregnant Swiss albino mice at different fetal growth periods were exposed to 150 R gamma rays in the presence or absence of 2-mercaptopropionylglycine (MPG), a SH radioprotector. The weights of litters born to these mothers were recorded at different postpartum intervals. There was an initial weight loss at 1 week after birth followed by a second weight loss after 4 weeks in the unprotected control males, whereas females showed continuous gains in weight from initial loss at 1 week. In the MPG-treated groups, the pattern of weight changes remained the same, but the loss was significantly less than in the controls and the second weight loss in the case of males was not obvious.

摘要

处于不同胎儿生长阶段的怀孕瑞士白化小鼠,在有或没有巯基放射保护剂2-巯基丙酰甘氨酸(MPG)的情况下,接受150伦琴的γ射线照射。记录这些母鼠所产幼崽在不同产后时间段的体重。未受保护的对照组雄性幼崽在出生后1周出现首次体重下降,4周后出现第二次体重下降,而雌性幼崽在出生1周出现最初体重下降后体重持续增加。在MPG处理组中,体重变化模式相同,但体重下降明显少于对照组,且雄性的第二次体重下降不明显。

相似文献

1
2-Mercaptopropionylglycine protection against growth-inhibiting effects in utero irradiated mice.2-巯基丙酰甘氨酸对子宫内受照射小鼠生长抑制作用的保护作用。
Acta Anat (Basel). 1982;112(3):249-53. doi: 10.1159/000145517.
2
Protection from body weight loss by 2-mercaptopropionylglycine (MPG) in growing mice irradiated in utero with gamma radiation.2-巯基丙酰甘氨酸(MPG)对子宫内受γ射线照射的生长小鼠体重减轻的保护作用。
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Effect of 2-mercaptopropionylglycine (MPG) on thyroid function in sub-lethally irradiated mice.2-巯基丙酰甘氨酸(MPG)对亚致死剂量照射小鼠甲状腺功能的影响。
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引用本文的文献

1
Protection from body weight loss by 2-mercaptopropionylglycine (MPG) in growing mice irradiated in utero with gamma radiation.2-巯基丙酰甘氨酸(MPG)对子宫内受γ射线照射的生长小鼠体重减轻的保护作用。
Experientia. 1982 Aug 15;38(8):962-3. doi: 10.1007/BF01953678.