From the Division of Pediatric Emergency Medicine.
Division of Pediatric Intensive Care, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Pediatr Emerg Care. 2021 Jun 1;37(6):308-311. doi: 10.1097/PEC.0000000000001580.
Carbon monoxide (CO) is a gas, which is produced by incomplete combustion of hydrocarbon-containing substances, and causes significant tissue and organ damage in the common event of CO poisoning. This study aims to evaluate the demographic, clinical, and laboratory characteristics of patients diagnosed with CO poisoning in the emergency department and to determine the factors associated with severe course in the acute phase of poisoning.
A total of 331 patients diagnosed with CO poisoning in Hacettepe University Children's Hospital, Pediatric Emergency Unit, between January 2004 and March 2014 were included in the study. Their demographic characteristics, presenting complaints, physical examination findings, Glasgow Coma Scale scores, carboxyhemoglobin, leukocyte, hemoglobin, troponin T, pH and lactate levels, type of treatment (normobaric or hyperbaric oxygen), intensive care unit admissions, and outcome of poisoning were investigated.
Ninety-three patients were given hyperbaric oxygen. Fifty-one patients were admitted to the pediatric intensive care unit, 18 patients have had a severe clinical course, and 6 patients have died. The risk factors associated with severe disease course were determined to be low Glasgow Coma Scale score, high leukocyte count, and high troponin T levels at presentation.
Glasgow Coma Scale score, leukocyte count, and troponin T level may be beneficial in predicting clinical outcomes and tailoring therapy in children with CO poisoning.
一氧化碳（CO）是一种气体，由含碳氢化合物物质不完全燃烧产生，在常见的 CO 中毒事件中会对组织和器官造成严重损伤。本研究旨在评估在急诊科诊断为 CO 中毒的患者的人口统计学、临床和实验室特征，并确定与中毒急性期严重病程相关的因素。
共有 331 例在 2004 年 1 月至 2014 年 3 月期间在哈塞特佩大学儿童医院儿科急诊部诊断为 CO 中毒的患者纳入本研究。研究调查了他们的人口统计学特征、主诉、体检发现、格拉斯哥昏迷量表评分、碳氧血红蛋白、白细胞、血红蛋白、肌钙蛋白 T、pH 值和乳酸水平、治疗类型（常压或高压氧）、入住重症监护病房和中毒结局。
93 例患者接受高压氧治疗。51 例患者入住儿科重症监护病房，51 例患者出现严重临床病程，6 例患者死亡。确定与严重疾病病程相关的危险因素为格拉斯哥昏迷量表评分低、白细胞计数高和肌钙蛋白 T 水平高。
格拉斯哥昏迷量表评分、白细胞计数和肌钙蛋白 T 水平可能有助于预测 CO 中毒儿童的临床结局，并为个体化治疗提供依据。
