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[高压氧治疗一氧化碳中毒]

[Hyperbaric oxygen for carbon monoxide poisoning].

作者信息

Abramovich A, Shupak A, Ramon Y, Shoshani O, Bentur Y, Bar-Josef G, Taitelman U

机构信息

Israel Naval Medical Institute, Israel Defense Forces Medical Corps, Haifa.

出版信息

Harefuah. 1997 Jan 1;132(1):21-4, 71.

PMID:9035576
Abstract

Severe cases of carbon monoxide (CO) poisoning from all over Israel are treated at the Israel Naval Medical Institute with hyperbaric oxygen (HBO). Between 1.11.94 and 15.2.95. 24 cases of CO poisoning were treated. Poisoning was usually due to domestic gas-fired heating systems, CO being the only toxin involved. Since delay between termination of CO exposure and arrival at the emergency department averaged 55 minutes, the level of carboxyhemoglobin measured on presentation did not always reflect the true severity of the poisoning. Poisoning was defined as severe and requiring HBO treatment when 1 or more of the following indications was present: evidence of neurological involvement, cardiographic signs of acute ischemic injury, metabolic acidosis, carboxyhemoglobin level greater than 25%, and pregnancy. 20 (84%) recovered consciousness during the course of 1 session (90 min.) of HBO treatment (pO2 2.8 ATA) or immediately thereafter, with resolution of other signs of CO poisoning. 3 required a second treatment session before their symptoms resolved. A patient who arrived in deep coma with severe cerebral edema died. HBO is an important element in the combined treatment of severe CO poisoning. There should be greater awareness of the danger of CO poisoning and the means of preventing it, both among medical staff and the population as a whole, mainly in areas in which cold weather requires use of heating systems, which may be gas-fired.

摘要

以色列各地的重度一氧化碳(CO)中毒病例均在以色列海军医学研究所接受高压氧(HBO)治疗。在1994年11月1日至1995年2月15日期间,共治疗了24例CO中毒病例。中毒通常是由家用燃气供暖系统引起的,CO是唯一涉及的毒素。由于从停止接触CO到抵达急诊科的平均延迟时间为55分钟,因此就诊时测得的碳氧血红蛋白水平并不总能反映中毒的真实严重程度。当出现以下1项或多项指征时,中毒被定义为重度且需要HBO治疗:神经系统受累的证据、急性缺血性损伤的心电图体征、代谢性酸中毒、碳氧血红蛋白水平大于25%以及妊娠。20例(84%)患者在1次HBO治疗疗程(90分钟,pO2 2.8 ATA)过程中或之后立即恢复意识,同时CO中毒的其他体征也消失。3例患者在症状缓解前需要进行第2次治疗疗程。1例深度昏迷且伴有严重脑水肿的患者死亡。HBO是重度CO中毒综合治疗中的重要组成部分。医护人员和全体民众,尤其是在寒冷天气需要使用可能以燃气为燃料的供暖系统的地区,都应该提高对CO中毒危险及其预防方法的认识。

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