Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fujian, China.
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fujian, China.
Oral Dis. 2019 Jan;25(1):80-86. doi: 10.1111/odi.12957. Epub 2018 Sep 6.
Limited evidence exists on the roles of serum copper (Cu) and zinc (Zn) in oral cancer risk. We aimed to preliminarily explore the association between serum Cu and Zn levels and oral cancer risk with relatively large-scale samples.
Serum Cu and Zn levels of 344 oral cancer patients and 1,122 matched healthy controls in this case-control study were measured by inductively coupled plasma mass spectrometry (ICP-MS).
Restricted cubic spline revealed the U-shaped relationship between serum Cu or Zn levels and the risk of oral cancer. Serum deficient or elevated levels of Cu were significantly associated with the risk of oral cancer: The ORs were 1.38 (95% CI: 1.01-1.89) and 2.82 (95% CI: 1.60-4.98), respectively. The positive association of serum low or high levels of Zn with oral cancer risk was also observed: The ORs were 2.72 (95% CI: 1.60-4.62) and 12.41 (95% CI: 9.09-16.93), respectively. Additionally, there were multiplicative interactions between the aforementioned trace elements and smoking.
This preliminary study suggests that both serum excess and deficient levels of Cu or Zn were significant correlation with oral cancer risk, which may provide a new insight on the roles of serum Cu and Zn in oral cancer.
关于血清铜（Cu）和锌（Zn）在口腔癌风险中的作用，目前证据有限。我们旨在通过较大规模的样本初步探讨血清 Cu 和 Zn 水平与口腔癌风险之间的关系。
本病例对照研究共检测了 344 例口腔癌患者和 1122 例匹配健康对照者的血清 Cu 和 Zn 水平，采用电感耦合等离子体质谱法（ICP-MS）进行检测。
限制性立方样条分析显示血清 Cu 或 Zn 水平与口腔癌风险之间存在 U 型关系。血清 Cu 缺乏或升高水平与口腔癌风险显著相关：比值比（OR）分别为 1.38（95%可信区间：1.01-1.89）和 2.82（95%可信区间：1.60-4.98）。血清 Zn 低或高水平与口腔癌风险呈正相关：OR 分别为 2.72（95%可信区间：1.60-4.62）和 12.41（95%可信区间：9.09-16.93）。此外，上述微量元素与吸烟之间存在乘法交互作用。
本初步研究表明，血清 Cu 或 Zn 水平过高或过低与口腔癌风险显著相关，这可能为血清 Cu 和 Zn 在口腔癌中的作用提供新的见解。
