癌症特异性剪接变化与剪接衍生新抗原的潜力。
Cancer-Specific Splicing Changes and the Potential for Splicing-Derived Neoantigens.
机构信息
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 408 E. 69th Street, New York, NY 10065, USA; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Pathology, Stony Brook University, New York, NY 10065, USA.
Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, 408 E. 69th Street, New York, NY 10065, USA; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
出版信息
Cancer Cell. 2018 Aug 13;34(2):181-183. doi: 10.1016/j.ccell.2018.07.008.
Abstract
In this issue of Cancer Cell, Kahles et al. perform a comprehensive analysis of RNA splicing across cancer types and identify novel correlations between genetic alterations and splicing in cancer. In addition, they identify that tumor-specific splicing has the potential to generate a large new class of tumor-specific neoantigens.
摘要
在本期《癌细胞》中，Kahles 等人对癌症类型中的 RNA 剪接进行了全面分析，并发现了遗传改变与癌症中剪接之间的新关联。此外，他们还发现肿瘤特异性剪接有可能产生大量新的肿瘤特异性新生抗原。
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本文引用的文献
1
Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients.对 8705 例肿瘤患者的可变剪接进行全面分析。
Cancer Cell. 2018 Aug 13;34(2):211-224.e6. doi: 10.1016/j.ccell.2018.07.001. Epub 2018 Aug 2.
2
Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types.剪接因子基因的体细胞突变景观及其在 33 种癌症类型中的功能后果。
Cell Rep. 2018 Apr 3;23(1):282-296.e4. doi: 10.1016/j.celrep.2018.01.088.
3
Systematic Analysis of Splice-Site-Creating Mutations in Cancer.系统分析癌症中的剪接位点突变。
Cell Rep. 2018 Apr 3;23(1):270-281.e3. doi: 10.1016/j.celrep.2018.03.052.
4
Detection of Proteome Diversity Resulted from Alternative Splicing is Limited by Trypsin Cleavage Specificity.检测由可变剪接导致的蛋白质组多样性受到胰蛋白酶切割特异性的限制。
Mol Cell Proteomics. 2018 Mar;17(3):422-430. doi: 10.1074/mcp.RA117.000155. Epub 2017 Dec 8.
5
The Functional Impact of Alternative Splicing in Cancer.可变剪接在癌症中的功能影响
Cell Rep. 2017 Aug 29;20(9):2215-2226. doi: 10.1016/j.celrep.2017.08.012.
6
SplAdder: identification, quantification and testing of alternative splicing events from RNA-Seq data.SplAdder：从RNA测序数据中识别、定量和检测可变剪接事件
Bioinformatics. 2016 Jun 15;32(12):1840-7. doi: 10.1093/bioinformatics/btw076. Epub 2016 Feb 11.
7
Identification of common genetic variants controlling transcript isoform variation in human whole blood.人类全血中控制转录本异构体变异的常见遗传变异的鉴定。
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8
Noisy splicing drives mRNA isoform diversity in human cells.嘈杂剪接驱动人类细胞中 mRNA 异构体多样性。
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9
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Hum Mol Genet. 2006 Mar 1;15(5):777-87. doi: 10.1093/hmg/ddi492. Epub 2006 Jan 25.
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