Department of Dental Hygiene, Gachon University College of Health Science, Incheon, Republic of Korea.
Department of Preventive Dentistry and Public Oral Health, Oral Science Research Center, Brain Korea 21 PLUS Project, College of Dentistry, Yonsei University, Seoul, Republic of Korea.
Photodiagnosis Photodyn Ther. 2018 Sep;23:367-372. doi: 10.1016/j.pdpdt.2018.08.007. Epub 2018 Aug 11.
Early detection and diagnosis of incipient caries are the keys to achieving a favorable prognosis. Monitoring of pathological changes based on clinical evidence leads to an accurate prognosis. Therefore, this clinical study investigated changes in minerals of incipient carious lesions using quantitative light-induced fluorescence-digital (QLF-D) after applying professional fluoride treatment to children, with improvement of the lesion severity assessed based on the fluorescence loss (ΔF) value obtained using QLF-D.
This study examined 90 incipient enamel lesions on the primary teeth of 27 children aged between 4 and 10 years. QLF-D images were obtained before and after the application of 1.23% acidulated phosphate fluoride gel for 1 min, and the ΔF values at 0 and 4 weeks (ΔF and ΔF, respectively) and the recovery rates (R) of the lesions were evaluated. Receiver operating characteristic curve analysis was used to calculate the cutoff ΔF value at which recovery of the lesion with fluoride treatment remained feasible.
The recovery patterns of ΔF 4 weeks after fluoride application differed depending on the ΔF values. The incipient lesions with ΔF values of less than -13.00 recovered 4 weeks after fluoride application (P < 0.001) and had an average R value of 19.27%. The results indicate that a ΔF cutoff value can be determined for predicting the effects of remineralization after fluoride application and quantitative prognostic data can be provided to patients.
早期发现和诊断早期龋齿是获得良好预后的关键。基于临床证据监测病理变化可做出准确的预后。因此,本临床研究通过定量光诱导荧光数字(QLF-D)技术,在对儿童进行专业氟化物治疗后,检测早期龋损病变中矿物质的变化,根据 QLF-D 获得的荧光损失(ΔF)值评估病变严重程度的改善。
本研究检查了 27 名 4-10 岁儿童的 90 颗原发性牙齿的早期釉质病变。在应用 1.23%酸性磷酸氟凝胶 1 分钟前后获得 QLF-D 图像,并评估 0 周和 4 周时的 ΔF 值(分别为ΔF 和ΔF)和病变的恢复率(R)。采用受试者工作特征曲线分析计算氟化物治疗后病变恢复可行的 ΔF 截止值。
氟化物应用后 4 周时 ΔF 的恢复模式因 ΔF 值而异。氟化物应用后 4 周,ΔF 值小于-13.00 的早期病变恢复(P < 0.001),平均 R 值为 19.27%。结果表明,可以确定一个 ΔF 截止值来预测氟化物应用后的再矿化效果,并为患者提供定量预后数据。