Department of Dental Hygiene, Gachon University College of Health Science, Republic of Korea.
Department of Preventive Dentistry & Public Oral Health, BK21 PLUS Project, Oral Science Research Center, Yonsei University College of Dentistry, Republic of Korea.
Photodiagnosis Photodyn Ther. 2018 Sep;23:45-49. doi: 10.1016/j.pdpdt.2018.05.008. Epub 2018 May 12.
The aim of this in situ study was to measure baseline fluorescence loss values (ΔF) using the quantitative light-induced fluorescence (QLF) technology to screen enamel lesions for effective remineralization following fluoride application.
In this single-blinded in situ study, 20 adult volunteers wore intraoral appliances containing 4 specimens of human enamel. The surfaces of the specimens were divided into 3 regions: sound, demineralized, and treated regions. After generating 80 artificial enamel lesions with varying ΔF values, all specimens were covered with 1.23% acidulated phosphate fluoride gel for 1 min. Three repeated QLF-digital measures of ΔF values were then obtained for the lesions, immediately after demineralization and at 1 and 4 weeks after fluoride application.
Fluoride application was found to increase the ΔF values of lesions significantly over time (p < 0.001). The groups with lower ΔF values showed significantly larger changes in ΔF values over time (p < 0.001). Receiver operating characteristics analysis showed that baseline lesion values of ΔF = -17.50 and -25.50 would allow for lesion ΔF to recover to -10 at 1 and 4 weeks after fluoride application, respectively (p < 0.001). The findings of this study indicate that clinicians can establish prognostic criteria for early carious lesions using the QLF technology, and hence predict the efficacy of fluoride treatment and devise effective lesion-specific treatment plans.
本原位研究的目的是使用定量光诱导荧光（QLF）技术测量基线荧光损失值（ΔF），以筛选氟化物应用后牙釉质病变的有效再矿化。
在这项单盲原位研究中，20 名成年志愿者佩戴含有 4 个人类牙釉质样本的口腔内器械。样本的表面分为 3 个区域：健康区、脱矿区和处理区。在产生具有不同 ΔF 值的 80 个人工牙釉质病变后，所有样本均用 1.23%酸性磷酸氟凝胶覆盖 1 分钟。然后，在脱矿后立即以及氟化物应用后 1 周和 4 周，对病变进行了 3 次重复的 QLF-数字 ΔF 值测量。
氟化物应用随着时间的推移显著增加了病变的 ΔF 值（p<0.001）。ΔF 值较低的组随时间的变化，ΔF 值的变化明显更大（p<0.001）。受试者工作特征分析显示，基线病变 ΔF 值为-17.50 和-25.50 时，分别允许病变 ΔF 在氟化物应用后 1 周和 4 周恢复至-10（p<0.001）。这项研究的结果表明，临床医生可以使用 QLF 技术为早期龋病建立预后标准，从而预测氟化物治疗的效果，并制定有效的病变特异性治疗计划。
