School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Nov;126(5):390-403. doi: 10.1016/j.oooo.2018.06.007. Epub 2018 Jun 30.
The aim of this study was to evaluate the efficacy of platelet-rich fibrin (PRF) after bone surgery compared to surgery alone in the treatment of medication-related osteonecrosis of the jaw (MRONJ).
A total of 47 patients with diagnosis of stage II or III of MRONJ were recruited at the Academic Hospital of Magna Graecia University of Catanzaro and allocated to 2 groups: In the first, patients were treated with PRF in addition to surgery (PRF group), in the other, only bone surgery was performed (non-PRF group). Fisher's exact and Student t tests were used to evaluate differences between the 2 surgical protocols in terms of mucosal integrity, absence of infection, and pain evaluation at scheduled follow-ups of 1 month (T1), 6 months (T2), and 1 year (T3).
Analysis of mucosal integrity, absence of infection, and pain evaluation showed a significant difference between the 2 groups in favor of PRF only at T1 (P < .05), whereas no differences were determined at T2 and T3 (P > .05).
Our results suggested that local application of PRF after bone surgery may improve the quality of life limited to the short-term follow-up and reduce pain and postoperative infections.
本研究旨在评估富血小板纤维蛋白（PRF）在颌骨骨髓炎（MRONJ）治疗中的疗效，与单纯手术相比。
共有 47 名诊断为 II 期或 III 期 MRONJ 的患者在卡坦扎罗 Magna Graecia 大学附属医院接受治疗，并分为两组：第一组患者在手术治疗的基础上添加 PRF（PRF 组），另一组仅接受骨手术治疗（非 PRF 组）。Fisher 确切概率检验和学生 t 检验用于评估两组手术方案在预定随访 1 个月（T1）、6 个月（T2）和 1 年（T3）时的黏膜完整性、无感染和疼痛评估方面的差异。
分析黏膜完整性、无感染和疼痛评估显示，PRF 组在 T1 时的结果明显优于非 PRF 组（P <.05），而在 T2 和 T3 时没有差异（P >.05）。
我们的结果表明，在骨手术后局部应用 PRF 可能会提高生活质量，仅限于短期随访，并减轻疼痛和术后感染。
