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What are the drugs of the future?未来的药物有哪些?
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本文引用的文献

1
The Pharmaceutical Industry in 2017. An Analysis of FDA Drug Approvals from the Perspective of Molecules.2017 年制药行业。从分子角度对 FDA 药物批准的分析。
Molecules. 2018 Feb 27;23(3):533. doi: 10.3390/molecules23030533.
2
Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB.使用整个 PDB 的镜像生成高稳定性生物活性螺旋肽的 D-氨基酸类似物的方法。
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1505-1510. doi: 10.1073/pnas.1711837115. Epub 2018 Jan 29.
3
New 2016 Data and Statistics for Global Pharmaceutical Products and Projections through 2017.2016年全球药品新数据与统计以及到2017年的预测。
ACS Chem Neurosci. 2017 Aug 16;8(8):1635-1636. doi: 10.1021/acschemneuro.7b00253.
4
Small-molecule inhibitors of protein-protein interactions: progressing toward the reality.蛋白质-蛋白质相互作用的小分子抑制剂:迈向现实
Chem Biol. 2014 Sep 18;21(9):1102-14. doi: 10.1016/j.chembiol.2014.09.001.
5
Defining the difference: What Makes Biologics Unique.界定差异:生物制剂的独特之处
Biotechnol Healthc. 2004 Sep;1(4):24-9.

未来的药物有哪些?

What are the drugs of the future?

作者信息

Ngo Huy X, Garneau-Tsodikova Sylvie

机构信息

University of Kentucky , 789 South Limestone Street , Lexington , KY 40536-0596 , USA . Email:

出版信息

Medchemcomm. 2018 Apr 23;9(5):757-758. doi: 10.1039/c8md90019a. eCollection 2018 May 1.

DOI:10.1039/c8md90019a
PMID:30108965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6072476/
Abstract

Are small molecules or biologics the drugs of the future? Small-molecule drugs have historically been the pillars of traditional medicine. However, recently, we seem to be amidst a scientific revolution with the rise of many FDA-approved biologic drugs. This opinion article looks at the current state of small molecules and biologics and assesses what the future holds for these two broad classes of drugs.

摘要

小分子药物还是生物制剂将成为未来的药物?从历史上看,小分子药物一直是传统医学的支柱。然而,最近,随着许多获得美国食品药品监督管理局(FDA)批准的生物制剂药物的兴起,我们似乎正处于一场科学革命之中。这篇观点文章审视了小分子药物和生物制剂的现状,并评估了这两大类药物的未来走向。