Walz-Cicconi M A, Rose R M, Dammin G J, Weller T H
Arch Virol. 1986;88(3-4):265-77. doi: 10.1007/BF01310880.
Guinea pigs were inoculated by the respiratory route with wild-type (Cyr) or vaccine (Oka) strain varicella zoster virus (VZV). Wild-type cell-free virus obtained by sonication produced neutralizing antibody responses in steroid-treated animals when given via the intratracheal route, and induced neutralizing antibody as well as a pneumonitis in normal animals when given via the intrabronchial (i.b.) route. A humoral response also followed i.b. instillation of cell-associated wild-type or vaccine strain VZV. Prior i.b. administration of thioglycollate or exposure to hyperoxia altered the number and function of pulmonary macrophages, respectively, but viral susceptibility of the guinea pigs was not enhanced. Both strains of VZV could be isolated from bronchial washings up to 48 hours after i.b. instillation of cell-associated virus, but neither strain was isolated thereafter from cultures of bronchial washings or explanted lung tissues.
豚鼠通过呼吸道接种野生型（Cyr）或疫苗株（Oka）水痘带状疱疹病毒（VZV）。通过超声处理获得的野生型无细胞病毒，经气管内途径给予时，在接受类固醇治疗的动物中产生中和抗体反应；经支气管内（i.b.）途径给予时，在正常动物中诱导产生中和抗体以及肺炎。支气管内滴注细胞相关的野生型或疫苗株VZV后也会出现体液反应。预先经支气管内给予巯基乙酸盐或暴露于高氧环境分别改变了肺巨噬细胞的数量和功能，但豚鼠对病毒的易感性并未增强。在支气管内滴注细胞相关病毒后48小时内，两种VZV毒株均可从支气管灌洗液中分离出来，但此后在支气管灌洗液或离体肺组织培养物中均未分离到任何一种毒株。
