Lopes Caroline Maria Igrejas, Cavalcanti Marília Cabral, Alves E Luna Ana Cláudia, Marques Kátia Maria Gonçalves, Rodrigues Maria José, DE Menezes Valdenice Aparecida
Universidade de Pernambuco - UPE, School of Dentistry, Camaragibe, PE, Brazil.
Universidade de São Paulo - USP, School of Dentistry, São Paulo, SP, Brazil.
Braz Oral Res. 2018 Aug 13;32:e87. doi: 10.1590/1807-3107bor-2018.vol32.0087.
Sickle cell anemia, a genetic disease caused by a mutation in the beta-globin gene, can present oral manifestations such as delayed tooth eruption and hypomineralized enamel and dentin. The aim of the present study was to evaluate the prevalence and severity of developmental defects of enamel (DDE) and delayed tooth eruption in children with sickle cell anemia. The sample comprised 56 male and female children with sickle cell anemia aged 6 to 12 years and treated at the Hematology and Hemotherapy Center of Pernambuco, Brazil. The data were collected according to the WHO criteria for DDE and tooth eruption. The prevalence of DDE was 58.2% and increased with age, affecting 43.8% of children aged 6 to 8 years and 66.7% of those aged 10 to 12 years (p>0.05; Pearson's chi-square test). There was no significant association between DDE and sex; the most prevalent type of DDE was diffuse opacity (6.2%). Tooth eruption was delayed in 18 children (32.1%). The delay increased with age and was detected in 11.8% of children aged 6 to 8 years, in 20.0% of those aged 8 to 10 years and in 54.2% of those aged 10 to 12 years (p<0.05; Pearson's chi-square test). Delayed tooth eruption was higher in males (36.7%, p>0.05). The prevalence of DDE was high, increased with age and was similar between sexes, while delayed eruption was higher in males and showed a significant association with age.
镰状细胞贫血是一种由β-珠蛋白基因突变引起的遗传性疾病，可出现诸如牙齿萌出延迟以及牙釉质和牙本质矿化不全等口腔表现。本研究的目的是评估镰状细胞贫血患儿牙釉质发育缺陷（DDE）和牙齿萌出延迟的患病率及严重程度。样本包括56名年龄在6至12岁之间、在巴西伯南布哥州血液学和血液治疗中心接受治疗的镰状细胞贫血男女患儿。根据世界卫生组织关于DDE和牙齿萌出的标准收集数据。DDE的患病率为58.2%，且随年龄增加，6至8岁儿童中有43.8%受影响，10至12岁儿童中有66.7%受影响（p>0.05；Pearson卡方检验）。DDE与性别之间无显著关联；最常见的DDE类型是弥漫性混浊（占6.2%）。18名儿童（32.1%）牙齿萌出延迟。延迟情况随年龄增加，在6至8岁儿童中有11.8%出现，8至10岁儿童中有20.0%出现，10至12岁儿童中有54.2%出现（p<0.05；Pearson卡方检验）。男性牙齿萌出延迟情况更高（36.7%，p>0.05）。DDE患病率高，随年龄增加，且男女之间相似，而牙齿萌出延迟在男性中更高且与年龄有显著关联。
