Guirassy Mouhamadou Lamine, Baglo Folly Emmanuel, Diallo Ahmad Moustapha, Mbow Ndeye Lira, Thiam Diabel, Seck-Diallo Adam, Benoist Henri Michel
Service of Periodontology, Institute of Odontology and Stomatology (IOS), Faculty of Medicine, Pharmacy and Odontostomatology, Cheikh Anta Diop University of Dakar, Senegal.
J Adv Periodontol Implant Dent. 2025 Apr 13;17(2):103-110. doi: 10.34172/japid.025.3467. eCollection 2025 Jun.
Sickle cell disease is a genetic disorder that manifests itself in several organs. There is little consensus in the literature on oral manifestations, particularly dental and periodontal. This study aimed to identify the oral manifestations of sickle cell disease, focusing on dental and periodontal manifestations.
An electronic search was performed in PubMed, Embase, and African Index Medicus. Quality and risk of bias were assessed using the Newcastle-Ottawa Scale, the modified Newcastle-Ottawa Scale, and the 2013 Guideline CARE. This systematic review covered research published between 2000 and 2022.
A total of 962 articles were identified, 26 of which were selected, including 13 case-control studies, 4 cohort studies, 7 cross-sectional studies, and 2 case reports. The risk of bias was high for 3.84% of the studies, medium for 38.46%, and low for 57.60%. Oral manifestations were reported in 24 studies, with a predominance of periodontal ones in 10 studies. An association between sickle cell disease and dental caries, pulpal necrosis, and delayed tooth eruption has been reported.
Several oral manifestations, particularly periodontal, of sickle cell disease have been reported. However, current data do not provide evidence of a possible association between sickle cell disease and oral symptoms, particularly periodontal manifestations.
镰状细胞病是一种在多个器官表现出来的遗传性疾病。关于口腔表现，尤其是牙齿和牙周方面，文献中几乎没有共识。本研究旨在确定镰状细胞病的口腔表现，重点关注牙齿和牙周表现。
在PubMed、Embase和非洲医学索引中进行了电子检索。使用纽卡斯尔-渥太华量表、改良的纽卡斯尔-渥太华量表和2013年CARE指南评估质量和偏倚风险。本系统评价涵盖了2000年至2022年发表的研究。
共识别出962篇文章，其中26篇被选中，包括13项病例对照研究、4项队列研究、7项横断面研究和2篇病例报告。3.84%的研究偏倚风险高，38.46%为中度，57.60%为低度。24项研究报告了口腔表现，其中10项研究以牙周表现为主。据报道，镰状细胞病与龋齿、牙髓坏死和牙齿萌出延迟之间存在关联。
已有报道称镰状细胞病有多种口腔表现，尤其是牙周表现。然而，目前的数据并未提供镰状细胞病与口腔症状，尤其是牙周表现之间可能存在关联的证据。
