Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
College of Chemistry, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
Angew Chem Int Ed Engl. 2018 Oct 1;57(40):13114-13119. doi: 10.1002/anie.201807158. Epub 2018 Sep 11.
Carriers that can afford tunable physical and structural changes are envisioned to address critical issues in controlled drug delivery applications. Herein, photo-responsive conjugated polymer nanoparticles (CPNs) functionalized with donor-acceptor Stenhouse adduct (DASA) and folic acid units for controlled drug delivery and imaging are reported. Upon visible-light (λ=550 nm) irradiation, CPNs simultaneously undergo structure, color, and polarity changes that release encapsulated drugs into the cells. The backbone of CPNs favors FRET to DASA units boosting their fluorescence. Notably, drug-loaded CPNs exhibit excellent biocompatibility in the dark, indicating perfect control of the light trigger over drug release. Delivery of both hydrophilic and hydrophobic drugs with good loading efficiency was demonstrated. This strategy enables remotely controlled drug delivery with visible-light irradiation, which sets an example for designing delivery vehicles for non-invasive therapeutics.
可实现物理和结构可调的载体被认为可以解决控制药物输送应用中的关键问题。在此，报告了用光响应共轭聚合物纳米粒子（CPNs），其通过供体-受体 Stenhouse 加合物（DASA）和叶酸单元进行功能化，用于控制药物输送和成像。在可见光（λ=550nm）照射下，CPNs 同时经历结构、颜色和极性变化，将包裹的药物释放到细胞中。CPNs 的骨架有利于 DASA 单元的 FRET，从而增强其荧光。值得注意的是，载药的 CPN 在黑暗中表现出良好的生物相容性，表明对药物释放的光触发具有完美的控制。已证明具有良好载药效率的亲水和疏水药物的输送。该策略实现了可见光照射的远程控制药物输送，为设计非侵入性治疗的输送载体树立了榜样。
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