混合次氯酸钠和 QMix 2in1 后形成的沉淀物的核磁共振波谱和红外光谱分析。
Nuclear magnetic resonance spectroscopy and infrared spectroscopy analysis of precipitate formed after mixing sodium hypochlorite and QMix 2in1.
机构信息
Department of Restorative Dentistry, Faculty of Dentistry, Eskişehir Osmangazi University, Eskişehir, Turkey.
Department of Endodontics, Faculty of Dentistry, Eskişehir Osmangazi University, Eskişehir, Turkey.
出版信息
PLoS One. 2018 Aug 15;13(8):e0202081. doi: 10.1371/journal.pone.0202081. eCollection 2018.
BACKGROUND
Mixing sodium hypochlorite (NaOCl) with chlorhexidine (CHX) forms a brown precipitate. QMix-2in1 (QMix) was introduced as a final irrigant. Manufacturer recommends interim flushing with saline between the application of NaOCl and QMix to prevent formation of precipitation. This study assessed whether para-chloroaniline (PCA) is formed after mixing NaOCl with QMix.
METHODS
Commercially available, 5.25% NaOCl solution, 2% CHX, QMix, 15% ethylenediaminetetraacetic acid (EDTA) and 98% PCA in powder form were used. Groups were prepared at room temperature. Group 1, 98% PCA in powder form; Group 2, 2% chlorhexidine (CHX); Group 3, QMix; Group 4, 5.25% sodium hypochlorite (NaOCl) mixed with QMix; Group 5, 5.25% NaOCl mixed with CHX; Group 6, 15% EDTA mixed with CHX. The precipitates were extracted and analysed with Proton Nuclear Magnetic Resonance (1H-NMR) and Infrared (IR) Spectroscopy, using PCA as an internal standard.
RESULTS
No PCA was found in any of the irrigant-mixture groups tested.
CONCLUSIONS
This study used the interpretation of spectral results for the amino signals of precipitate formed after mixing QMix with 5.25% NaOCl using different nondestructive analysis methods, with PCA as an internal standard (control). We conclude that mixing QMix or 2%CHX with 5.25% NaOCl does not yield free PCA.
背景
次氯酸钠（NaOCl）与洗必泰（CHX）混合会形成棕色沉淀。QMix-2in1（QMix）作为最终冲洗液被引入。制造商建议在 NaOCl 和 QMix 之间应用之间用生理盐水进行中间冲洗，以防止沉淀形成。本研究评估了将 QMix 与 NaOCl 混合后是否形成对氯苯胺（PCA）。
方法
使用市售的 5.25% NaOCl 溶液、2% CHX、QMix、15%乙二胺四乙酸（EDTA）和粉末形式的 98% PCA。在室温下制备组。第 1 组：粉末形式的 98% PCA；第 2 组：2% CHX；第 3 组：QMix；第 4 组：与 QMix 混合的 5.25%次氯酸钠（NaOCl）；第 5 组：与 CHX 混合的 5.25% NaOCl；第 6 组：与 CHX 混合的 15% EDTA。使用 PCA 作为内标，提取沉淀并进行质子核磁共振（1H-NMR）和红外（IR）光谱分析。
结果
在所测试的冲洗液混合组中均未发现 PCA。
结论
本研究使用不同的非破坏性分析方法，使用 PCA 作为内标（对照），对 QMix 与 5.25% NaOCl 混合后形成的沉淀的氨基信号的光谱结果进行解释。我们得出结论，混合 QMix 或 2%CHX 与 5.25% NaOCl 不会产生游离 PCA。
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