核磁共振法测定离子物种的结合常数：一项警示。
NMR Determination of the Binding Constant of Ionic Species: A Caveat.
作者信息
Schulz Nils, Schindler Severin, Huber Stefan M, Erdelyi Mate
机构信息
Faculty of Chemistry and Biochemistry, Organic Chemistry I , Ruhr-Universität Bochum , Universitätsstraße 150 , Bochum 44801 , Germany.
Department of Chemistry, BMC , Uppsala University , Uppsala SE-752 37 , Sweden.
出版信息
J Org Chem. 2018 Sep 21;83(18):10881-10886. doi: 10.1021/acs.joc.8b01567. Epub 2018 Aug 23.
Determination of the dissociation constant of ionic complexes with the standard NMR titration and NMR dilution techniques may yield a severely compromised result, due to the typically unconsidered chemical shift alteration induced by the gradual change of the ionic strength during the experiment. We show that the reliability of an NMR titration experiment is markedly improved upon keeping the overall ionic strength constant.
采用标准核磁共振滴定法和核磁共振稀释技术测定离子络合物的解离常数，可能会得到严重失真的结果，这是因为在实验过程中离子强度的逐渐变化通常会引起未被考虑的化学位移改变。我们发现，保持总离子强度恒定可显著提高核磁共振滴定实验的可靠性。
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