钩束和胼胝体压部各向异性分数在单相双相障碍、未受影响同胞和健康对照中的变化。
Fractional anisotropy of the uncinate fasciculus and cingulum in bipolar disorder type I, type II, unaffected siblings and healthy controls.
机构信息
scientific support staff,Cardiff University Brain Research Imaging Centre,Cardiff University,UK.
PhD student,MRC Centre for Neuropsychiatric Genetics and Genomics,Institute of Psychological Medicine and Clinical Neurosciences,Cardiff University,UK.
出版信息
Br J Psychiatry. 2018 Sep;213(3):548-554. doi: 10.1192/bjp.2018.101.
BACKGROUND
Fractional anisotropy in the uncinate fasciculus and the cingulum may be biomarkers for bipolar disorder and may even be distinctly affected in different subtypes of bipolar disorder, an area in need of further research.AimsThis study aims to establish if fractional anisotropy in the uncinate fasciculus and cingulum shows differences between healthy controls, patients with bipolar disorder type I (BD-I) and type II (BD-II), and their unaffected siblings.
METHOD
Fractional anisotropy measures from the uncinate fasciculus, cingulum body and parahippocampal cingulum were compared with tractography methods in 40 healthy controls, 32 patients with BD-I, 34 patients with BD-II, 17 siblings of patients with BD-I and 14 siblings of patients with BD-II.
RESULTS
The main effects were found in both the right and left uncinate fasciculus, with patients with BD-I showing significantly lower fractional anisotropy than both patients with BD-II and healthy controls. Participants with BD-II did not differ from healthy controls. Siblings showed similar effects in the left uncinate fasciculus. In a subsequent complementary analysis, we investigated the association between fractional anisotropy in the uncinate fasciculus and polygenic risk for bipolar disorder and psychosis in a large cohort (n = 570) of healthy participants. However, we found no significant association.
CONCLUSIONS
Fractional anisotropy in the uncinate fasciculus differs significantly between patients with BD-I and patients with BD-II and healthy controls. This supports the hypothesis of differences in the physiological sub-tract between bipolar disorder subtypes. Similar results were found in unaffected siblings, suggesting the potential for this biomarker to represent an endophenotype for BD-I. However, fractional anisotropy in the uncinate fasciculus seems unrelated to polygenic risk for bipolar disorder or psychosis.Declaration of interestNone.
背景
钩束和扣带束的各向异性分数可能是双相障碍的生物标志物，甚至在不同亚型的双相障碍中可能有明显的差异，这是一个需要进一步研究的领域。
目的
本研究旨在确定钩束和扣带束的各向异性分数在健康对照者、I 型双相障碍（BD-I）和 II 型双相障碍（BD-II）患者及其未受影响的兄弟姐妹之间是否存在差异。
方法
使用轨迹法比较了 40 名健康对照者、32 名 BD-I 患者、34 名 BD-II 患者、17 名 BD-I 患者的兄弟姐妹和 14 名 BD-II 患者的兄弟姐妹的钩束、扣带束体和海马旁扣带束的各向异性分数。
结果
在右钩束和左钩束均发现了主要影响，BD-I 患者的各向异性分数明显低于 BD-II 患者和健康对照者。BD-II 患者与健康对照者无差异。左钩束的兄弟姐妹也有类似的影响。在随后的补充分析中，我们在一个由 570 名健康参与者组成的大样本中研究了钩束的各向异性分数与双相障碍和精神病的多基因风险之间的关联。然而，我们没有发现显著的关联。
结论
BD-I 患者与 BD-II 患者和健康对照者的钩束各向异性分数有显著差异。这支持了双相障碍亚型之间在生理上存在差异的假设。未受影响的兄弟姐妹也有类似的结果，这表明该生物标志物可能代表 BD-I 的一个潜在表型。然而，钩束的各向异性分数与双相障碍或精神病的多基因风险似乎没有关系。
声明利益
无。
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