Zhang Zhi-Hua, Luo Fei, Su Yan-Hui, Li Jian
Department of Urology, Tianjin Union Medical Center, Hong-qiao District, Tianjin, China.
Medicine (Baltimore). 2018 Aug;97(33):e11862. doi: 10.1097/MD.0000000000011862.
The study is aiming to evaluate the treatment safety and efficacy of greenlight laser photovaporization of the prostate (PVP) combined with transurethral electrovaporization resection (TUVP) for elderly (≥ 70 years) men with lower urinary tract symptoms due to benign prostatic hyperplasia (BPH/LUTS) with a large prostate volume (≥ 80 mL). One hundred twelve BPH/LUTS patients treated with PVP were divided into 2 groups according to prostate volume (PV), the outcomes of the 2 groups were assessed at 12 months after the operation. Patients in the PV ≥ 80 group (n = 51) had a higher level of maximum detrusor pressure (Pdet.max) than those in the PV < 80 group (n = 61) (97.14 ± 36.68 vs 70.70 ± 32.55, P < .001). Pdet.max level of the 2 groups was significantly decreased at the end of follow-up. International Prostate Symptom Score questionnaires (IPSS) score, maximum flow rate (Qmax), and residual urine volume (PVR) were significantly improved in comparison to the preoperative status (P < .001). PVP combined with TUVP can significantly improve outcomes (IPSS, Qmax, PVR) and is a safe and effective technique for elderly BPH/LUTS patients with a large prostate volume.
本研究旨在评估绿激光前列腺汽化术（PVP）联合经尿道电汽化切除术（TUVP）治疗前列腺体积较大（≥80 mL）的老年（≥70岁）良性前列腺增生所致下尿路症状（BPH/LUTS）患者的治疗安全性和疗效。112例接受PVP治疗的BPH/LUTS患者根据前列腺体积（PV）分为2组，术后12个月评估两组的治疗结果。PV≥80组（n = 51）患者的最大逼尿肌压力（Pdet.max）水平高于PV＜80组（n = 61）患者（97.14±36.68 vs 70.70±32.55，P＜0.001）。随访结束时，两组的Pdet.max水平均显著降低。与术前状态相比，国际前列腺症状评分问卷（IPSS）评分、最大尿流率（Qmax）和残余尿量（PVR）均显著改善（P＜0.001）。PVP联合TUVP可显著改善治疗结果（IPSS、Qmax、PVR），是治疗前列腺体积较大的老年BPH/LUTS患者的一种安全有效的技术。
