The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders & Beijing Institute for Brain Disorders Center of Schizophrenia, Beijing Anding Hospital, Capital Medical University, No.5 Ankang Lane, Dewai Avenue, Xicheng District, Beijing, 100088, China.
The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China.
BMC Psychiatry. 2018 Aug 16;18(1):258. doi: 10.1186/s12888-018-1807-7.
Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and sensory gating in first-episode schizophrenia remains elusive.
Fifty-six patients and 49 age and sex-matched healthy controls were assessed using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) for CT and Positive and Negative Syndrome Scale (PANSS) for symptoms severity. Sensory gating was tested using the modified paradigm, perceived spatial separation-induced prepulse inhibition (PSS-PPI), and the perceived spatial co-location PPI (PSC-PPI or classical PPI).
Comparing with healthy controls, the patients had significantly higher score on sexual abuse (t = 2.729, p < 0.05), lower PSS- PPI, % (ISI = 120 ms and ISI = 60 ms) (t = - 3.089, - 4.196, p < 0.05). Univariate analysis revealed the absence of a significant correlation among CT, PPI paradigms and symptoms. However, multiple linear regression analyses demonstrated the CTQ-SF total was negatively associated with PSS PPI (ISI = 120 ms) (p = 0.018).
The current study illustrates that the impact of CT on sensory gating in patients with first-episode schizophrenia, and thus we conclude that CT may be a risk factor to the occurrence of schizophrenia through its impact on sensory gating.
童年创伤（CT）已被发现与精神分裂症的发病有关，而听觉感觉门控缺陷是精神分裂症的主要内表型之一。然而，首发精神分裂症患者 CT 与感觉门控之间的关联仍不清楚。
使用儿童创伤问卷-短式（CTQ-SF）评估 56 名患者和 49 名年龄和性别匹配的健康对照者的 CT，使用阳性和阴性综合征量表（PANSS）评估症状严重程度。使用改良范式（感知空间分离诱导的前脉冲抑制（PSS-PPI）和感知空间共定位 PPI（PSC-PPI 或经典 PPI））测试感觉门控。
与健康对照组相比，患者在性虐待方面的得分明显更高（t=2.729，p<0.05），PSS-PPI、%（ISI=120ms 和 ISI=60ms）较低（t=-3.089，-4.196，p<0.05）。单变量分析显示 CT 与 PPI 范式和症状之间没有显著相关性。然而，多元线性回归分析表明 CTQ-SF 总分与 PSS PPI（ISI=120ms）呈负相关（p=0.018）。
本研究表明 CT 对首发精神分裂症患者感觉门控的影响，因此我们得出结论，CT 可能通过影响感觉门控成为精神分裂症发生的一个风险因素。
