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卡巴胆碱和催产素刺激豚鼠子宫肌层中肌醇磷酸的生成。

Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium.

作者信息

Marc S, Leiber D, Harbon S

出版信息

FEBS Lett. 1986 May 26;201(1):9-14. doi: 10.1016/0014-5793(86)80561-0.

DOI:10.1016/0014-5793(86)80561-0
PMID:3011507
Abstract

In the guinea pig myometrium prelabelled with myo-[2-3H]inositol, carbachol and oxytocin enhanced a concentration-dependent and rapid release of IP3 which preceded that of IP2 and IP1. The specific receptor-mediated phospholipase C activation degrading PIP2 to IP3 did not require the presence of extracellular Ca2+. The ionophore A23187 as well as K+ depolarization failed to increase inositol phosphate accumulation. It is proposed that IP3 could have a role in the contraction of uterine smooth muscle elicited by the activation of muscarinic as well as of oxytocin receptors.

摘要

在预先用肌醇-[2-³H]标记的豚鼠子宫肌层中，卡巴胆碱和催产素可增强肌醇三磷酸（IP3）浓度依赖性的快速释放，且这种释放先于肌醇二磷酸（IP2）和肌醇一磷酸（IP1）。特异性受体介导的磷脂酶C激活将磷脂酰肌醇-4,5-二磷酸（PIP2）降解为IP3并不需要细胞外钙离子的存在。离子载体A23187以及钾离子去极化均未能增加肌醇磷酸的积累。有人提出，IP3可能在毒蕈碱受体和催产素受体激活所引发的子宫平滑肌收缩中发挥作用。

相似文献

1
Carbachol and oxytocin stimulate the generation of inositol phosphates in the guinea pig myometrium.卡巴胆碱和催产素刺激豚鼠子宫肌层中肌醇磷酸的生成。
FEBS Lett. 1986 May 26;201(1):9-14. doi: 10.1016/0014-5793(86)80561-0.
2
Fluoroaluminates mimic muscarinic- and oxytocin-receptor-mediated generation of inositol phosphates and contraction in the intact guinea-pig myometrium. Role for a pertussis/cholera-toxin-insensitive G protein.氟铝酸盐模拟毒蕈碱和催产素受体介导的豚鼠完整子宫肌层中肌醇磷酸的生成及收缩。一种对百日咳毒素/霍乱毒素不敏感的G蛋白的作用。
Biochem J. 1988 Oct 15;255(2):705-13.
3
Activation of beta-adrenergic receptors inhibits Ca2+ entry-mediated generation of inositol phosphates in the guinea pig myometrium, a cyclic AMP-independent event.β-肾上腺素能受体的激活抑制了豚鼠子宫肌层中由Ca2+内流介导的肌醇磷酸生成，这是一个不依赖环磷酸腺苷的事件。
Mol Pharmacol. 1992 Mar;41(3):509-19.
4
Carbachol causes rapid phosphodiesteratic cleavage of phosphatidylinositol 4,5-bisphosphate and accumulation of inositol phosphates in rabbit iris smooth muscle; prazosin inhibits noradrenaline- and ionophore A23187-stimulated accumulation of inositol phosphates.卡巴胆碱可导致兔虹膜平滑肌中磷脂酰肌醇4,5 -二磷酸的快速磷酸二酯酶裂解及肌醇磷酸的积累；哌唑嗪可抑制去甲肾上腺素和离子载体A23187刺激的肌醇磷酸积累。
Biochem J. 1984 Nov 15;224(1):291-300. doi: 10.1042/bj2240291.
5
Carbachol and sodium fluoride, but not TSH, stimulate the generation of inositol phosphates in the dog thyroid.
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6
Pharmacological evidence for distinct muscarinic receptor subtypes coupled to the inhibition of adenylate cyclase and to the increased generation of inositol phosphates in the guinea pig myometrium.豚鼠子宫肌层中与腺苷酸环化酶抑制及肌醇磷酸生成增加相关的不同毒蕈碱受体亚型的药理学证据。
J Pharmacol Exp Ther. 1990 Feb;252(2):800-9.
7
Muscarinic regulation of cytosolic free calcium in canine tracheal smooth muscle cells: Ca2+ requirement for phospholipase C activation.毒蕈碱对犬气管平滑肌细胞胞质游离钙的调节：磷脂酶C激活对钙离子的需求
Br J Pharmacol. 1993 Nov;110(3):1239-47. doi: 10.1111/j.1476-5381.1993.tb13948.x.
8
Correlative studies on the effect of carbachol on myo-inositol trisphosphate accumulation, myosin light chain phosphorylation and contraction in sphincter smooth muscle of rabbit iris.卡巴胆碱对兔虹膜括约肌平滑肌中肌醇三磷酸积累、肌球蛋白轻链磷酸化及收缩作用的相关性研究
J Pharmacol Exp Ther. 1986 Nov;239(2):574-83.
9
Calcium-dependence of histamine- and carbachol-induced inositol phosphate formation in human U373 MG astrocytoma cells: comparison with HeLa cells and brain slices.组胺和卡巴胆碱诱导人U373 MG星形细胞瘤细胞形成肌醇磷酸的钙依赖性：与HeLa细胞和脑切片的比较。
Br J Pharmacol. 1994 Feb;111(2):598-608. doi: 10.1111/j.1476-5381.1994.tb14779.x.
10
Beta adrenergic receptor activation attenuates the generation of inositol phosphates in the pregnant rat myometrium. Correlation with inhibition of Ca++ influx, a cAMP-independent mechanism.β肾上腺素能受体激活可减弱妊娠大鼠子宫肌层中肌醇磷酸的生成。与抑制Ca++内流的相关性，一种不依赖环磷酸腺苷的机制。
J Pharmacol Exp Ther. 1996 Jan;276(1):130-6.

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