Clinical Research Center, School of Optometry, University of California, 110 Minor Addition, Berkeley, CA 94720-2020, USA.
Clinical Research Center, School of Optometry, University of California, 110 Minor Addition, Berkeley, CA 94720-2020, USA; Vision Science Graduate Program, University of California, 360 Minor Hall, Berkeley, CA 94720-2020, USA.
Cont Lens Anterior Eye. 2018 Dec;41(6):496-500. doi: 10.1016/j.clae.2018.08.004. Epub 2018 Aug 14.
To quantify corneoscleral junction (CSJ) topography in soft contact lens (SCL) wearers, and assess the association between the CSJ and SCL performance and subjective comfort, forty-four adapted SCL wearers (16 Asians, 16 Caucasians, 12 Latinos) were recruited for the present study. Corneal topography was taken with a Medmont E300 (Medmont International, Pty Ltd.). CSJ images were taken with a commercial OCT (Bioptigen, Inc.). Our published CSJ image analysis technique was used to describe the geometric properties of the CSJ using the sum of squared orthogonalized residuals (SSRo). Multivariable mixed effects models were employed to examine associations between SSRo and subject demographics, ocular characteristics, SCL fit and performance, and comfort. The SSRo was significantly related to quadrant (p < 0.001), ethnicity (p = 0.014), and horizontal corneal shape factor (p = 0.044). The nasal quadrant had the largest SSRo, indicating the steepest CSJ profile and/or the most irregular CSJ surface, followed by the inferior quadrant. The superior and temporal quadrants had the smallest SSRo, indicating relatively flat and even CSJ topography. Caucasians had the steepest and/or most irregular CSJ compared with Latinos and Asians. Less inferior-superior heterogeneity in the SSRo was associated with greater comfort after 6 h of lens wear. The SSRo was proved to be a useful tool to quantify CSJ geometry in SCL wearers. Significant differences in the SSRo were found among quadrants and ethnic groups. Better subjective comfort after 6 h of SCL wear was associated with a smaller difference in the SSRo between the superior and inferior quadrants.
为了量化软性隐形眼镜（SCL）佩戴者的角膜缘巩膜交接（CSJ）形态，并评估 CSJ 与 SCL 性能和主观舒适度之间的关系，本研究招募了 44 名适应 SCL 的佩戴者（16 名亚洲人、16 名高加索人、12 名拉丁裔）。角膜地形图由 Medmont E300（Medmont International，Pty Ltd.）拍摄。CSJ 图像由商用 OCT（Bioptigen，Inc.）拍摄。我们发表的 CSJ 图像分析技术用于使用平方和正交残差（SSRo）描述 CSJ 的几何特性。多变量混合效应模型用于检查 SSRo 与受试者人口统计学、眼部特征、SCL 适配和性能以及舒适度之间的关联。SSRo 与象限（p<0.001）、种族（p=0.014）和水平角膜形状因子（p=0.044）显著相关。鼻象限的 SSRo 最大，表明 CSJ 轮廓最陡峭和/或 CSJ 表面最不规则，其次是下象限。上象限和颞象限的 SSRo 最小，表明 CSJ 地形相对平坦且均匀。与拉丁裔和亚洲人相比，高加索人具有最陡峭和/或最不规则的 CSJ。SSRo 中上下差异较小与佩戴 6 小时后舒适度更高相关。SSRo 被证明是一种量化 SCL 佩戴者 CSJ 几何形状的有用工具。在象限和种族之间发现了 SSRo 的显著差异。佩戴 6 小时 SCL 后主观舒适度更好与上、下象限之间 SSRo 差异较小相关。
