Azizpour Arghavan, Nasimi Maryam, Shakoei Safoura, Mohammadi Fariba, Azizpour Arsalan
Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Dermatology, Imam Khomeini Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Dermatol Pract Concept. 2018 Jul 31;8(3):163-165. doi: 10.5826/dpc.0803a01. eCollection 2018 Jul.
Bullous pemphigoid (BP) is described as a subepidermal blistering disorder, which is commonly reported among the elderly, particularly those older than 60 years of age. In this report, we present the case of a 41-year-old female patient with BP lesions that were initially detected at the site of Hijama therapy with a subsequent generalized spread. Punch biopsy from the lesions and perilesional direct immunofluorescence (DIF) demonstrated features of BP. The anti-BP180 level was 178 RU/mL, and the anti-BP230 level was negative. BP antigens at the site of Hijama caused an antibody response, which led to widespread blistering over the trunk due to epitope spreading. In a comprehensive review of the literature, a total of 22 BP patients with lesions due to physical trauma were studied, and clinical, immunological, and epidemiological information was gathered. This article is the first report on the occurrence of BP induced by Hijama therapy.
大疱性类天疱疮（BP）被描述为一种表皮下疱性疾病，常见于老年人，尤其是60岁以上的人群。在本报告中，我们介绍了一例41岁女性患者，其BP皮损最初在拔火罐治疗部位被发现，随后出现全身扩散。对皮损进行的打孔活检及皮损周围直接免疫荧光检查（DIF）显示出BP的特征。抗BP180水平为178 RU/mL，抗BP230水平为阴性。拔火罐部位的BP抗原引发了抗体反应，由于表位扩展导致躯干广泛出现水疱。在对文献的全面综述中，共研究了22例因物理创伤导致皮损的BP患者，并收集了临床、免疫学和流行病学信息。本文是关于拔火罐治疗诱发BP的首例报告。
