Pacy P J, Dodson P M, Fletcher R F
Int J Obes. 1986;10(1):43-52.
The effect of an intended diet, high in cereal fibre, low in fat and sodium was assessed over a 3-month period in 13 type 2 diabetic patients with moderate hypertension (diastolic blood pressure greater than 105 and less than 115 mmHg without antihypertension drug therapy). Eleven patients completed the study and two patients were withdrawn owing to an increase of blood pressure above initial values after 1 month. Using a compliance scoring system by an observer unaware of blood pressure response, patients were divided into those compliant to the dietary regimen (n = 7; group A) and those who were not, and therefore were considered controls (n = 4; group B). Group A demonstrated significant reductions in systolic (190.4 +/- 18 to 166.6 +/- 22.4 mmHg; P less than 0.02) and diastolic blood pressure (113.1 +/- 3.7 to 103.3 +/- 9.1 mmHg; P less than 0.01), weight (78.5 +/- 5.6 to 74.3 +/- 6.8 kg; P less than 0.02), daily urinary sodium excretion (210.3 +/- 79.9 to 120.3 +/- 56.1 mmol; P less than 0.02) and serum LDL levels (P less than 0.02). A reduction in glycosylated haemoglobin of 2.2 per cent was also noted. Three patients achieved a diastolic blood pressure level below 100 mmHg. In contrast, no significant changes occurred in group B. In particular, systolic and diastolic blood pressure (111.0 +/- 2.2 to 110.3 +/- 8.9 mmHg) remained unchanged. We conclude that the modified diet may have a hypotensive effect in diabetic subjects with moderate hypertension. However, the degree of blood pressure reduction suggests that this diet could, at best, only be considered an adjunct to conventional antihypertensive drug therapy.
对13例患有中度高血压（舒张压大于105且小于115mmHg，未接受抗高血压药物治疗）的2型糖尿病患者进行了为期3个月的研究，评估了一种高谷物纤维、低脂肪和低钠的目标饮食的效果。11例患者完成了研究，2例患者因1个月后血压高于初始值而退出。通过一名对血压反应不知情的观察者使用依从性评分系统，将患者分为依从饮食方案的患者（n = 7；A组）和不依从的患者，后者被视为对照组（n = 4；B组）。A组患者的收缩压（190.4±18至166.6±22.4mmHg；P＜0.02）和舒张压（113.1±3.7至103.3±9.1mmHg；P＜0.01）、体重（78.5±5.6至74.3±6.8kg；P＜0.02）、每日尿钠排泄量（210.3±79.9至120.3±56.1mmol；P＜0.02）和血清低密度脂蛋白水平（P＜0.02）均显著降低。糖化血红蛋白也降低了2.2%。3例患者的舒张压降至100mmHg以下。相比之下，B组没有显著变化。特别是，收缩压和舒张压（111.0±2.2至110.3±8.9mmHg）保持不变。我们得出结论，改良饮食可能对患有中度高血压的糖尿病患者有降压作用。然而，血压降低的程度表明，这种饮食充其量只能被视为传统抗高血压药物治疗的辅助手段。
