Pacy P J, Dodson P M, Kubicki A J, Fletcher R F, Taylor K G
Diabetes Res. 1984 Sep;1(3):159-63.
Fifty Type II diabetic patients with mild hypertension were treated by a high cereal fibre, low fat and low sodium diet in a controlled trial for a 3-month period. The modified diet and control diet groups were well matched although the control group had significantly increased levels of HDL2-cholesterol (p less than 0.05). The modified diet group had a significant reduction of mean serum triglyceride (p less than 0.05) and elevation of HDL2 (p less than 0.05) levels. There was also a reduction of systolic (p less than 0.001) and diastolic blood pressure (p less than 0.001), weight (p less than 0.01) and glycosylated haemoglobin (p less than 0.001). No changes were observed in the control group. In those patients with added hyperlipidaemia, dietary therapy resulted in a significant decrease of mean serum cholesterol (p less than 0.02), triglyceride (p less than 0.01) and glycosylated haemoglobin levels (p less than 0.01). The control group had a significant reduction of HDL-cholesterol (p less than 0.02). We conclude that a high cereal fibre, low fat and low sodium dietary regimen is associated with improvement in cardiovascular risk over a 3-month period, especially in those with hyperlipidaemia. Contrary to previous reports, no deleterious effect on serum triglyceride, HDL- and HDL2-cholesterol levels were recorded in this study. These data add further support to the recent dietary recommendations of several Diabetic Associations.
五十名轻度高血压的II型糖尿病患者在一项为期3个月的对照试验中接受了高谷物纤维、低脂肪和低钠饮食治疗。改良饮食组和对照组匹配良好，尽管对照组的HDL2-胆固醇水平显著升高（p<0.05）。改良饮食组的平均血清甘油三酯显著降低（p<0.05），HDL2水平升高（p<0.05）。收缩压（p<0.001）、舒张压（p<0.001）、体重（p<0.01）和糖化血红蛋白（p<0.001）也有所降低。对照组未观察到变化。在那些合并高脂血症的患者中，饮食治疗导致平均血清胆固醇（p<0.02）、甘油三酯（p<0.01）和糖化血红蛋白水平显著降低（p<0.01）。对照组的HDL-胆固醇显著降低（p<0.02）。我们得出结论，高谷物纤维、低脂肪和低钠饮食方案在3个月期间与心血管风险的改善相关，尤其是在高脂血症患者中。与先前的报道相反，本研究未记录到对血清甘油三酯、HDL-和HDL2-胆固醇水平的有害影响。这些数据进一步支持了几个糖尿病协会最近的饮食建议。
