Dodson P M, Stephenson J, Dodson L J, Kurnik D, Kritzinger E E, Taylor K G, Fletcher R F
Department of Medicine, Dudley Road Hospital, Birmingham, West Midlands, UK.
J Hum Hypertens. 1989 Jun;3(3):197-202.
Thirty-four patients with essential hypertension were allocated, in a controlled trial, to a treatment diet of high fibre, low fat and low sodium composition, or to a control diet by the hospital dietitian. Clinical observations were made by a separate 'blinded' nursing sister. After three months treatment, the modified diet-treated group showed a significant reduction in mean systolic (169.4 +/- 23.4 to 150.6 +/- 16.1 mmHg) and diastolic blood pressure (101.5 +/- 7.3 to 89.4 +/- 6.8 mmHg), accompanied by significant reductions in urinary sodium excretion (140.4 +/- 34.6 to 93.7 +/- 44 mmol/day) and weight (73.1 +/- 10 to 71.2 +/- 8.4 kg). The changes in control were; systolic 171.2 +/- 14.1 to 162.1 +/- 19.5 mmHg and diastolic pressure 97.2 +/- 10.8 to 91.7 +/- 9.7 mmHg. The mean differences in reductions between treated and control were 8.8 mmHg Systolic (95% confidence intervals: -2.6 to 21.2 mmHg) and 7.0 mmHg diastolic blood pressure (95% confidence intervals: 0.4 to 14.4 mmHg). The number of patients with normal blood pressure in the diet treated group at three months was double that in the control (eleven versus five). No relationships were shown between blood pressure changes and those of weight or urinary sodium excretion during the trial. The findings in this study are broadly in agreement with similar ones in essential hypertension and suggest that this form of dietary regimen has a clinically worthwhile hypotensive effect and this should be readily achievable in routine clinical practice.
在一项对照试验中,34名原发性高血压患者被医院营养师分配至高纤维、低脂肪和低钠成分的治疗饮食组,或对照饮食组。由另一位“不知情”的护士进行临床观察。治疗三个月后,改良饮食治疗组的平均收缩压(从169.4±23.4降至150.6±16.1 mmHg)和舒张压(从101.5±7.3降至89.4±6.8 mmHg)显著降低,同时尿钠排泄量(从140.4±34.6降至93.7±44 mmol/天)和体重(从73.1±10降至71.2±8.4 kg)也显著降低。对照组的变化为:收缩压从171.2±14.1降至162.1±19.5 mmHg,舒张压从97.2±10.8降至91.7±9.7 mmHg。治疗组与对照组血压降低的平均差异为收缩压8.8 mmHg(95%置信区间:-2.6至21.2 mmHg),舒张压7.0 mmHg(95%置信区间:0.4至14.4 mmHg)。饮食治疗组三个月时血压正常的患者数量是对照组的两倍(分别为11例和5例)。试验期间未发现血压变化与体重或尿钠排泄变化之间存在关联。本研究结果与原发性高血压的类似研究结果大致一致,表明这种饮食方案具有临床上值得重视的降压效果,且在常规临床实践中应易于实现。