Lange Frédéric, Peyrin Françoise, Montcel Bruno
Appl Opt. 2018 Aug 1;57(22):6417-6429. doi: 10.1364/AO.57.006417.
We have developed a broadband time-resolved multi-channel near-infrared spectroscopy system that can monitor the physiological responses of the adult human brain. This system is composed of a supercontinuum laser for the source part and of an intensified charge-coupled device camera coupled with an imaging spectrometer for the detection part. It allows the detection of the spectral, from 600 to 900 nm, and spatial dimensions as well as the arrival time of photon information simultaneously. We describe the setup and its characterization in terms of temporal instrument response function, wavelength sensitivity, and stability. The ability of the system to detect the hemodynamic response is then demonstrated. First, an in vivo experiment on an adult volunteer was performed to monitor the response in the arm during a cuff occlusion. Second, the response in the brain during a cognitive task was monitored on a group of five healthy volunteers. Moreover, looking at the response at different time windows, we could monitor the hemodynamic response in depth, enhancing the detection of the cortical activation. Those first results demonstrate the ability of our system to discriminate between the responses of superficial and deep tissues, addressing an important issue in functional near-infrared spectroscopy.
我们开发了一种宽带时间分辨多通道近红外光谱系统，该系统可监测成年人类大脑的生理反应。该系统由用于光源部分的超连续谱激光器和用于检测部分的与成像光谱仪耦合的增强型电荷耦合器件相机组成。它能够同时检测600至900纳米的光谱维度、空间维度以及光子信息的到达时间。我们从时间仪器响应函数、波长灵敏度和稳定性方面描述了该装置及其特性。然后展示了该系统检测血液动力学反应的能力。首先，对一名成年志愿者进行了一项体内实验，以监测袖带阻断期间手臂的反应。其次，对一组五名健康志愿者在认知任务期间大脑的反应进行了监测。此外，通过观察不同时间窗口的反应，我们可以深入监测血液动力学反应，增强对皮质激活的检测。这些初步结果证明了我们的系统能够区分浅表组织和深部组织的反应，解决了功能近红外光谱中的一个重要问题。
