近红外多波长、多通道、时间分辨光谱仪的研制及其在脑血流动力学和代谢测量中的应用。
Development of a near infrared multi-wavelength, multi-channel, time-resolved spectrometer for measuring brain tissue haemodynamics and metabolism.
机构信息
Department of Medical Physics & Bioengineering, University College London, Malet Place Eng. Building, Gower Street, London, WC1E 6BT, UK.
出版信息
Adv Exp Med Biol. 2014;812:181-186. doi: 10.1007/978-1-4939-0620-8_24.
We present a novel time domain functional near infrared spectroscopy system using a supercontinuum laser allowing us to measure the coefficient of absorption and scattering of up to 16 multiplexed wavelengths in the near infrared region. This is a four detector system that generates up to 3 mW of light for each wavelength with a narrow 2-3 nm FWHM bandwidth between 650 and 890 nm; each measurement of 16 wavelengths per channel can be performed up to a rate of 1 Hz. We can therefore quantify absolute haemoglobin changes in tissue and are currently investigating which and how many wavelengths are needed to resolve additional chromophores in tissue, such as water and the oxidation state of cytochrome-c-oxidase.
我们提出了一种新的基于超连续谱激光的时域近红外光谱系统，该系统可以测量近红外区域多达 16 个复用波长的吸收和散射系数。这是一个四探测器系统，每个波长可产生高达 3 mW 的光，在 650 至 890nm 之间的半峰全宽（FWHM）带宽狭窄至 2-3nm；每个通道的 16 个波长的测量可以达到 1Hz 的速率。因此，我们可以定量组织中血红蛋白的绝对变化，目前正在研究需要多少个以及哪些波长才能解析组织中的其他色团，如水和细胞色素 c 氧化酶的氧化态。
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