Villanueva A L, Schlosser C, Hopper B, Liu J H, Hoffman D I, Rebar R W
J Clin Endocrinol Metab. 1986 Jul;63(1):133-6. doi: 10.1210/jcem-63-1-133.
Because we previously found increased basal serum cortisol levels in women runners, we examined adrenocortical function in amenorrheic running women (AR), eumenorrheic running women (R), and normal nonexercising women (NC) in further detail. Mean 24-h urinary cortisol levels were significantly elevated (P less than 0.001) in six AR [45.1 +/- 7.2 (+/- SEM) micrograms/24 h] and eight R (38.5 +/- 6.9 micrograms/24 h) compared to four NC (13.9 +/- 2.8 micrograms/24 h). After adrenal suppression with 2 mg dexamethasone, integrated responses and absolute maximal elevations in serum cortisol levels in response to 10 micrograms/m2 exogenous ACTH (1-24) administered as an iv bolus dose, were not significantly different among six AR, six R, and six NC. This dose of ACTH results in maximal steroid release. The disappearance rates of cortisol (5 mg, iv) after dexamethasone suppression were similar in four AR, five R, and four NC and corresponded to a two-compartment model with mean half-lives of 4.9 and 93.8 min, respectively. Cortisol-binding globulin levels were also similar among the groups. These data document higher cortisol secretion and suggest increased ACTH secretion in running women.
由于我们之前发现女性跑步者的基础血清皮质醇水平升高，因此我们进一步详细研究了闭经跑步女性（AR）、月经正常跑步女性（R）和正常不运动女性（NC）的肾上腺皮质功能。与4名NC女性（13.9±2.8微克/24小时）相比，6名AR女性（45.1±7.2（±SEM）微克/24小时）和8名R女性（38.5±6.9微克/24小时）的24小时尿皮质醇平均水平显著升高（P<0.001）。在用2毫克地塞米松抑制肾上腺后，6名AR女性、6名R女性和6名NC女性在静脉推注10微克/平方米外源性促肾上腺皮质激素（1-24）后，血清皮质醇水平的综合反应和绝对最大升高无显著差异。该剂量的促肾上腺皮质激素可导致最大类固醇释放。在4名AR女性、5名R女性和4名NC女性中，地塞米松抑制后皮质醇（5毫克，静脉注射）的消失率相似，符合二室模型，平均半衰期分别为4.9分钟和93.8分钟。各组之间的皮质醇结合球蛋白水平也相似。这些数据表明跑步女性的皮质醇分泌更高，并提示促肾上腺皮质激素分泌增加。
