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自噬延长寿命：增强自噬延缓衰老。

Self-Digestion for Lifespan Extension: Enhanced Autophagy Delays Aging.

机构信息

Oncology Research & Development, Pfizer, Pearl River, NY 10965, USA.

Oncology Research & Development, Pfizer, Pearl River, NY 10965, USA.

出版信息

Mol Cell. 2018 Aug 16;71(4):485-486. doi: 10.1016/j.molcel.2018.08.002.

DOI:10.1016/j.molcel.2018.08.002
PMID:30118677
Abstract

By systemically boosting autophagy with a knockin mutation that prevents binding of beclin 1 to BCL2, Fernández et al. (2018) demonstrate that enhanced autophagy prolongs lifespan in mammals.

摘要

通过敲入突变系统地增强自噬，从而阻止 beclin 1 与 BCL2 的结合，Fernández 等人（2018 年）证明增强的自噬可以延长哺乳动物的寿命。

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