National Center for Women and Children's Health, Chinese Center for Disease Control and Prevention, Beijing, China.
Department of Ophthalmology, Maternal and Children's Hospital, Kunming, Yunnan, China.
Br J Ophthalmol. 2018 Dec;102(12):1742-1746. doi: 10.1136/bjophthalmol-2018-312366. Epub 2018 Aug 17.
The prevalence of ocular abnormalities of newborn in China has seldom been reported. To report the implementation of digital imaging in ocular screening of all newborns in multiple centres in China and to describe the abnormal findings of fundus examination, we did the cross-sectional study.
Fundus examinations were performed on newborns within the 42 days after birth using a RetCam wide-field digital imaging system. Digital images of the posterior pole, superior, nasal and temporal retinal fields of each participant were taken. All newborns were from eights centres across China from January 2009 to July 2017.
A total of 199 851 newborns were included in the study. We detected 18 198 (9.11%) abnormal cases. The most frequent abnormality was severe retinal haemorrhage (RH) found in 12 810 cases (6.41%). The other anomalies included familial exudative vitreoretinopathy, retinopathy of prematurity, abnormal fundus pigmentation, subconjunctival haemorrhage, choroidal coloboma, idiopathic retinal venous tortuosity, exudative changes and other anomalies with uncertain identities.
This large-scale study of newborn fundus examination showed a relatively high prevalence of ocular abnormalities. Hundreds of neonates with rare disorders that severely impair ocular health were also detected at an early age. The long-term impact of other anomalies including RHs on the ocular system should be investigated by a perspective study. Our study suggested that fundus examination of newborns can play a beneficial role in ocular health.
中国鲜有关于新生儿眼部异常的报道。为了报告在中国多个中心对所有新生儿进行眼部筛查的数字成像实施情况，并描述眼底检查的异常发现，我们进行了这项横断面研究。
使用 RetCam 宽视野数字成像系统对出生后 42 天内的新生儿进行眼底检查。对每个参与者的后极、上、鼻和颞视网膜视野拍摄数字图像。所有新生儿均来自中国 8 个中心，于 2009 年 1 月至 2017 年 7 月入组。
共纳入 199851 例新生儿。我们发现 18198 例（9.11%）异常病例。最常见的异常是严重视网膜出血（RH），共 12810 例（6.41%）。其他异常包括家族性渗出性玻璃体视网膜病变、早产儿视网膜病变、眼底色素异常、结膜下出血、脉络膜缺损、特发性视网膜静脉迂曲、渗出性改变和其他身份不明的异常。
这项大规模的新生儿眼底检查研究显示，眼部异常的发生率相对较高。还在早期发现了数百例严重影响眼部健康的罕见疾病新生儿。应通过前瞻性研究来调查 RH 等其他异常对眼部系统的长期影响。我们的研究表明，新生儿眼底检查对眼部健康有益。
