Anhui Province Maternity and Child Health Hospital, Maternity and Child Health Hospital affiliated to Anhui Medical University, Hefei, 230001, China.
School of Information Science and Technology, University of Science and Technology of China, Hefei, 230022, Anhui, China.
BMC Ophthalmol. 2023 Apr 5;23(1):139. doi: 10.1186/s12886-023-02884-7.
Familial exudative vitreoretinopathy (FEVR) is a rare congenital disorder of retinal vascular development. We aimed to study the vascular characteristics around the optic disc in neonates with FEVR and the relationship with disease severity.
A retrospective, case-control study including 43 (58 eyes) newborn patients with FEVR at stages 1 to 3 and 30 (53 eyes) age-matched normal full-term newborns was conducted. The peripapillary vessel tortuosity (VT), vessel width (VW) and vessel density (VD) were quantified by computer technology. The t-distributed stochastic neighbor embedding (t-SNE) algorithm was used to visualize the relationship between the severity of FEVR and the characteristics of perioptic disc vascular parameters.
The peripapillary VT, VW and VD were significantly increased in the FEVR group compared with the control group (P < 0.05). Subgroup analysis showed that VW and VD increased significantly with progressing FEVR stage (P < 0.05). And only VT in stage 3 FEVR was significantly increased compared with stage 1 and stage 2 (P < 0.05). After controlling the confounders, ordinal logistic regression analysis indicated that the VW (aOR: 1.75, P = 0.0002) and VD (aOR: 2.41, P = 0.0170) were significantly independent correlated with the FEVR stage, but VT (aOR: 1.07, P = 0.5454) was not correlated with FEVR staging. Visual analysis based on the t-SNE algorithm showed that peri-optic disc vascular parameters had a continuity along the direction of FEVR severity.
In the neonatal population, there were significant differences in peripapillary vascular parameters between patients with FEVR and normal subjects. Quantitative measurement of vascular parameters around the optic disc can be used as one of the indicators to assess the severity of FEVR.
家族性渗出性玻璃体视网膜病变（FEVR）是一种罕见的先天性视网膜血管发育异常。本研究旨在探讨 FEVR 新生儿视盘周围血管特征及其与疾病严重程度的关系。
回顾性病例对照研究纳入了 43 例（58 只眼）处于 1 至 3 期的 FEVR 新生儿和 30 例（53 只眼）年龄匹配的正常足月新生儿。通过计算机技术定量评估视盘周围血管迂曲度（VT）、血管宽度（VW）和血管密度（VD）。采用 t 分布随机邻嵌入（t-SNE）算法可视化 FEVR 严重程度与视盘周围血管参数特征之间的关系。
FEVR 组视盘周围 VT、VW 和 VD 显著高于对照组（P<0.05）。亚组分析显示，随着 FEVR 分期进展，VW 和 VD 显著增加（P<0.05）。仅 3 期 FEVR 的 VT 显著高于 1 期和 2 期（P<0.05）。控制混杂因素后，有序多因素逻辑回归分析表明，VW（比值比：1.75，P=0.0002）和 VD（比值比：2.41，P=0.0170）与 FEVR 分期显著相关，但 VT（比值比：1.07，P=0.5454）与 FEVR 分期无相关性。基于 t-SNE 算法的可视化分析表明，视盘周围血管参数在 FEVR 严重程度方向上具有连续性。
在新生儿人群中，FEVR 患者与正常对照者视盘周围血管参数存在显著差异。定量测量视盘周围血管参数可作为评估 FEVR 严重程度的指标之一。
